Early Ga-68 FAPI PET/MR after a heart attack
Official title: Early Ga-68 FAPI PET/MR for Assessment of Left Ventricular Remodeling After Acute Myocardial Infarction: A Prospective Single-Center Observational Study
Run by Ankara University · NCT07684924 · Data updated 2026-11-12
This study tests whether Ga-68 FAPI PET/MR done about 10 days after an acute myocardial infarction can predict how the heart will remodel over the next few months.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Ankara University Academic / other |
| Locations | 1 site (Ankara) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | June 29, 2028 |
| Study ends | June 29, 2028 |
| Registry record updated | July 27, 2026 |
| Trial ID | NCT07684924 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older with a recent AMI who have undergone successful coronary revascularization (if indicated) and can undergo FAPI PET/MR.
✕Probably not a fit
Patients with MRI contraindications, pregnancy, or conditions preventing follow-up MRI may not benefit from this imaging approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-center observational study uses Ga-68 FAPI PET/MR to image activated fibroblasts roughly 10 days post-AMI and then tracks left ventricular remodeling with serial cardiac MRI at 3 and 6 months. The goal is to see if early fibroblast activity is associated with later changes in ventricular function and scar formation. Participants undergo PET/MR imaging and standard clinical assessments; results may reveal imaging biomarkers linked to adverse remodeling. The study does not assign an intervention and will observe natural post-infarction remodeling processes.
Why it matters
Potential benefit: If successful, the imaging marker could help identify patients at higher risk of adverse remodeling and guide closer monitoring or future therapies.
How similar studies have gone: Prior work has shown feasibility of FAPI imaging in cardiac remodeling, but this exact early post-AMI FAPI PET/MR approach is relatively novel and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years. * Diagnosis of acute myocardial infarction according to current guideline criteria. * Successful coronary revascularization when clinically indicated. * Ability to undergo FAPI PET/MR. * Written informed consent. Exclusion Criteria: * Contraindications to MRI (e.g., non-MR-compatible implanted devices, severe claustrophobia). * Pregnancy or breastfeeding. * Severe renal impairment precluding gadolinium administration (if contrast-enhanced MR is performed). * Inability to provide informed consent. * Any condition considered by the investigator to interfere with study participation.
Where it's running
-
Ankara University Faculty of Medicine, Department of Nuclear Medicine
Ankara, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Elgin Ozkan, Prof.Dr.
- Email: ozkanelgin@yahoo.com
- Phone: +90 312 595 6445
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.