Early detection of psychiatric disorders using neurophysiological methods
Official title: An Integrated Neurophysiological Approach Toward the Early Detection of Psychiatric Disorders
Run by IRCCS Centro San Giovanni di Dio Fatebenefratelli · NCT06886945 · Data updated 2026-11-12
This study is trying to see if special tests on how people process sounds and sights can help find early signs of schizophrenia in individuals who may be at risk.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | IRCCS Centro San Giovanni di Dio Fatebenefratelli Academic / other |
| Locations | 1 site (Brescia, BS) |
| Status | Recruiting |
| Started | April 9, 2024 |
| Main results expected | October 2025 |
| Study ends | October 2025 |
| Registry record updated | March 20, 2025 |
| Trial ID | NCT06886945 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a clinical diagnosis of schizophrenia spectrum disorder and those exhibiting high schizotypal traits.
✕Probably not a fit
Patients with major physical illnesses, drug dependency, or other major psychiatric disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the early detection of schizophrenia and related disorders by examining sensory and perceptual processing in individuals with schizotypal traits and those diagnosed with schizophrenia. Participants will complete audio-visual perceptual tasks, specifically a modified version of the Sound-Induced Flash Illusion, to assess their multisensory integration capabilities. The research aims to identify potential biomarkers for early intervention in psychosis-prone individuals, addressing a significant gap in current clinical practices. By understanding the neurophysiological underpinnings of these disorders, the study seeks to improve risk mitigation strategies for at-risk populations.
Why it matters
Potential benefit: If successful, this study could lead to earlier identification and intervention for individuals at risk of developing schizophrenia.
How similar studies have gone: While the approach of using neurophysiological methods for early detection is promising, it remains largely novel and untested in this specific context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria (all participants): * Normal hearing * Normal or corrected-to-normal vision Inclusion Criteria (patients): * Clinical diagnosis of schizophrenia spectrum disorder (according to DSM-5) * IQ \> 70 Exclusion Criteria (all participants): * Anamnesis or evidence of any central nervous system alteration Exclusion Criteria (patients) * Current major physical illness * Drug dependency/abuse over the last 6 months * Unstable pharmacological therapy * Comorbidities with other major psychiatric disorders
Where it's running
-
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Brescia, Bs, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.