Does Paracetamol Change Gut Hormones, Glucose Absorption, and Blood Sugar in Healthy Young Adults
Official title: Does Paracetamol Influence the Release of Gut Hormones, Glucose Absorption and Glycemia?
Run by University of Copenhagen · NCT07821515 · Data updated 2026-11-12
This study tests whether taking paracetamol can influence gut hormone release and how the body absorbs glucose in healthy young adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 12 (estimated) |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 2 sites (Copenhagen, Capital and 1 other locations) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | September 30, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT07821515 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 18–25 with normal fasting glucose and BMI 20–25, who are not pregnant, not on medications affecting gastric function, and able to pause certain drugs.
✕Probably not a fit
Individuals with gastrointestinal diseases, ongoing medication influencing GI motility, or recent paracetamol/NSAID use may not benefit from or may be ineligible for the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial uses a randomized, placebo-controlled design to examine acute effects of paracetamol on endogenous prostaglandin synthesis and its impact on gut hormones, glucose absorption, and glycemia in healthy volunteers. Participants receive paracetamol or placebo and undergo measurements related to gut hormone release and blood glucose handling. Eligible adults are non-diabetic, with normal BMI and no major GI issues, and must pause certain medications before testing. The study aims to clarify potential metabolic effects of paracetamol beyond pain relief.
Why it matters
Potential benefit: If successful, the findings could improve understanding of how paracetamol affects gut hormones and glucose metabolism in healthy individuals.
How similar studies have gone: Prior research has explored paracetamol’s metabolic effects in various contexts, but this specific gut-hormone and glucose absorption focus in healthy adults is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Nondiabetic fasting plasma glucose (\< 7.0 mmol/L) at time of inclusion * BMI of 20-25 * Written informed consent Exclusion Criteria: * Haemoglobin \< 7.9 mmol/L * Pregnancy or breastfeeding * Significant gastrointestinal symptoms (e.g. dyspepsia, postprandial pain) * Use of medication that cannot be paused for 12 hours or any drug that affects gastric emptying, small intestinal motility, glucose absorption. * Use of paracetamol, NSAID, aspirin or similar within the previous week. * Evidence of drug abuse, consumption of tobacco in any form or daily consumption of more than 20g alcohol * History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery including cholecystectomy (but not uncomplicated appendicectomy) * Participation in other research studies within the previous 3 months * Inability to give informed consent * Intolerance to any of the components of paracetamol and the meals used for the study
Where it's running
-
Department of Biomedical Sciences, The Panum Institute, University of Copenhagen,
Copenhagen, Capital, Denmark Recruiting -
Hvidovre Hospital, Copenhagen University Hospital
Hvidovre, Denmark Recruiting
Study contacts
- Principal investigator: Simon Veedfald, MD, PhD — Department of BIomedical Scienes, University Copenhagen
- Study coordinator: Simon Veedfald, MD, PhD
- Email: veedfald@sund.ku.dk
- Phone: +45 41102595
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.