Understanding how heart rate affects blood flow in the brain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the relationship between heart rate and cerebral blood flow (CBF) in the middle cerebral artery (MCA) by utilizing temporary pacing catheters in patients undergoing elective electrophysiological procedures. Researchers will measure MCA CBF using transcranial Doppler ultrasound while manipulating heart rate to assess its impact on CBF. The study focuses particularly on patients with postural tachycardia syndrome (POTS), who often experience chronic orthostatic symptoms and reduced cardiac output. By investigating this relationship, the study seeks to enhance understanding of the hemodynamic determinants of CBF and potentially improve quality of life for affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female
* Age 18-70 years, inclusive
* Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium
* Left ventricular ejection fraction ≥50%
* Able and willing to provide informed consent
* Able to travel to the Cardiac Electrophysiology Laboratory at the Foothills Medical Centre, Calgary, Alberta, Canada

Exclusion Criteria:

* Unable or unwilling to provide informed consent
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol

Where it's running

• Foothills Medical Center
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Satish R Raj, MD MSCI — University of Calgary
• Study coordinator: Satish R Raj, MD MSCI
• Email: satish.raj@ucalgary.ca
• Phone: 403-210-6152

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.