Direct Selective Laser Trabeculoplasty to lower eye pressure in non‑Caucasian adults with open-angle glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will undergo DSLT in one or both eyes and have vision and intraocular pressure measured at baseline (after medication washout) and at 1, 3, and 6 months after the procedure. The main outcome is the change in washed‑out intraocular pressure at 6 months compared with washed‑out baseline, with success defined as a ≥20% IOP reduction. The study will also report the proportion of eyes free of glaucoma medications at 6 months, the need for additional treatments, and outcomes stratified by trabecular meshwork pigmentation. Eligible participants are adults of Black African descent with mild to moderate primary open‑angle glaucoma and baseline washed‑out IOP between 21 and 32 mmHg.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients of Black African descent scheduled to undergo DSLT treatment in one or both eyes.
* Diagnosis of mild to moderate primary open angle glaucoma (POAG).
* Mild to moderate POAG will be defined as Stage 2 or better of the Hodapp-Anderson-Parrish glaucoma staging system.
* Treatment naive or washed out IOP at time 0 ranging from ≥ 21 through 32 mm Hg.

Exclusion Criteria:

* Screened patients who were on IOP-lowering medications who did not successfully complete medication washout at the time of the procedure (time 0).
* Previous glaucoma surgeries/interventions:
* Patients who have undergone prior glaucoma-related procedures (e.g., trabeculectomy, laser trabeculoplasty, MIGS, or tube shunt).
* Secondary glaucoma:
* Patients with secondary forms of glaucoma, such as angle-closure glaucoma, neovascular glaucoma, or glaucoma resulting from trauma or other systemic diseases.
* Other significant ocular conditions including advanced cataracts, retinal diseases (e.g., age-related macular degeneration), or any condition that might complicate the assessment of intraocular pressure (IOP) or visual function as deemed by the investigator.
* Subjects who are pregnant, breast-feeding, or intend to become pregnant during the study period as determined by verbal inquiry.

Where it's running

• Select Eye Care
  Elkridge, Maryland, United States Recruiting

Study contacts

• Study coordinator: Scott E LaBorwit, MD
• Email: scott.laborwit@vipeyes.com
• Phone: 410-821-6400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.