Different ventilator breathing ratios (I:E 1:2 vs 1:3) during children's dental anesthesia
A Clinical Study on the Effects of Different Inspiratory:Expiratory Ratios on Respiratory Function and Recovery in Pediatric Patients Undergoing Dental Procedures Under General Anesthesia
We will try two mechanical ventilation timing patterns (I:E 1:2 versus 1:3) in children aged 2–12 to see which helps breathing and recovery go more smoothly after dental procedures under general anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 2 Years to 12 Years |
| Sex | All |
| Sponsor | Kırıkkale University Academic / other |
| Locations | 1 site (Kirikkale) |
| Trial ID | NCT07323420 on ClinicalTrials.gov |
What this trial studies
This is an observational study comparing two routine inspiratory:expiratory (I:E) ratios used during mechanical ventilation in children undergoing dental procedures under general anesthesia. The I:E ratio is typically adjusted about 20–30 minutes before the end of the procedure to ease the transition to spontaneous breathing, and the study will record which ratio (1:2 or 1:3) is used as part of standard care. Researchers will collect vital signs, respiratory parameters, time to spontaneous breathing, and recovery quality using a non-invasive emergence scoring system without adding extra tests or interventions. The goal is to relate these routine ventilation practices to respiratory complications and recovery metrics after extubation.
Who should consider this trial
Good fit: Children aged 2–12 years with ASA Physical Status I or II scheduled for dental procedures under general anesthesia at the study center whose parents or guardians consent are ideal candidates.
Not a fit: Children with significant airway or lung disease, ASA III or higher, known difficult airways, ages outside 2–12 years, very short (<1 hour) or very long (>3 hours) anesthesia durations, or those receiving medications that alter spontaneous breathing are unlikely to benefit from these specific findings.
Why it matters
Potential benefit: If successful, using a 1:3 I:E ratio could lead to smoother emergence, fewer respiratory issues, and faster recovery for children after dental general anesthesia.
How similar studies have performed: Some adult and critical care ventilation studies suggest prolonging expiration can improve respiratory efficiency, but applying a 1:3 I:E ratio specifically to pediatric dental anesthesia emergence is relatively novel and not well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients scheduled for dental procedures under general anesthesia at our faculty. * American Society of Anesthesiologists (ASA) Physical Status I or II. * Age between 2 and 12 years. * Written informed consent obtained from parents or legal guardians. Exclusion Criteria: * Patients whose parents or legal guardians decline participation. * Presence of adenoid hypertrophy \>30%. * Macroglossia or retrognathia. * Severe obesity or developmental delay. * History of delayed emergence from anesthesia. * ASA Physical Status III or higher. * Anesthesia duration less than 1 hour or more than 3 hours. * Patients with difficult airway management or ventilation. * Known pulmonary or airway diseases or anomalies. * Use of pharmacological agents that may affect spontaneous respiratory quality. * Presence of neuromuscular disorders affecting respiratory function. * Age \<2 years or \>12 years. * Administration of medications intraoperatively or preoperatively that may influence respiratory dynamics during emergence (e.g., atropine, lidocaine, steroids).
Where this trial is running
Kirikkale
- Kırıkkale University, Faculty of Dentistry — Kirikkale, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Gözde Nur Erkan Assisstant Professor
- Email: dr.gozdenur@gmail.com
- Phone: +903182244927
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.