Dietary changes for living kidney donors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of different dietary interventions on living kidney donors prior to transplantation. Participants will be assigned to one of four dietary regimes: a fasting mimicking diet, a ketogenic diet, a dietary restriction of sulfur-containing amino acids, or a control diet. The study aims to identify molecular changes in kidney biopsy samples that may enhance stress resistance and protect against acute kidney injury (AKI). By understanding these mechanisms, the research seeks to improve outcomes for kidney donors and recipients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients \> 18 years of age
* Planed living kidney transplantation (both donor and recipient are eligible)
* Written informed consent

Exclusion Criteria:

* Vegetarian lifestyle
* Body-Mass-Index (BMI) \< 18.5 kg/m2
* Calorie-reduced diet within the preceding four weeks
* Underlying wasting syndrome
* Contraindication for enteral nutrition
* Known allergy to or intolerance of the ingredients of the diet used
* Pregnancy
* Breastfeeding
* Absence of safe contraceptive measures or non-occurrence of menopause (in women)
* Participation in other interventional trials

Where it's running

• Department II of Internal Medicine, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne
  Cologne, Germany Recruiting

Study contacts

• Principal investigator: Roman-Ulrich Müller, Prof. MD — Department II of Internal Medicine, University Hospital of Cologne
• Study coordinator: Felix Köhler, MD
• Email: felix.koehler@uk-koeln.de
• Phone: +49 221 478 97222

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.