Dietary changes for living kidney donors
Dietary Interventions During Living Kidney Donations (DILKID Trial)
This study is testing different diets for living kidney donors to see if they can help protect their kidneys and improve health before surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Cologne Academic / other |
| Locations | 1 site (Cologne) |
| Trial ID | NCT05709600 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of different dietary interventions on living kidney donors prior to transplantation. Participants will be assigned to one of four dietary regimes: a fasting mimicking diet, a ketogenic diet, a dietary restriction of sulfur-containing amino acids, or a control diet. The study aims to identify molecular changes in kidney biopsy samples that may enhance stress resistance and protect against acute kidney injury (AKI). By understanding these mechanisms, the research seeks to improve outcomes for kidney donors and recipients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are planned living kidney donors or recipients.
Not a fit: Patients who are vegetarian, have a low BMI, or have contraindications for enteral nutrition may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved kidney function and reduced risk of acute kidney injury in living kidney donors.
How similar studies have performed: While dietary interventions have shown promise in animal models, this specific approach in living kidney donors is novel and has not been extensively tested in clinical settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \> 18 years of age * Planed living kidney transplantation (both donor and recipient are eligible) * Written informed consent Exclusion Criteria: * Vegetarian lifestyle * Body-Mass-Index (BMI) \< 18.5 kg/m2 * Calorie-reduced diet within the preceding four weeks * Underlying wasting syndrome * Contraindication for enteral nutrition * Known allergy to or intolerance of the ingredients of the diet used * Pregnancy * Breastfeeding * Absence of safe contraceptive measures or non-occurrence of menopause (in women) * Participation in other interventional trials
Where this trial is running
Cologne
- Department II of Internal Medicine, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne — Cologne, Germany (Recruiting)
Study contacts
- Principal investigator: Roman-Ulrich Müller, Prof. MD — Department II of Internal Medicine, University Hospital of Cologne
- Study coordinator: Felix Köhler, MD
- Email: felix.koehler@uk-koeln.de
- Phone: +49 221 478 97222
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.