Managing sodium levels in patients with severe kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the regulation of extracellular sodium levels in patients with end-stage renal disease who are undergoing volume and electrolyte challenges. It focuses on the effects of water and sodium chloride administration on patients with hyponatremia, a common electrolyte disorder. By monitoring intracellular measurements, the study aims to understand how these interventions can restore osmotic balance and improve patient outcomes. The research targets adult patients requiring renal replacement therapy and aims to provide insights into effective management strategies for electrolyte imbalances.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients ≥18 years
* Requirement of renal replacement therapy due to surgical (i.e., nephrectomy) or non-surgical (chronic kidney disease) reason
* Stable hemodialysis treatment for at least 3 months
* Urine output \<100ml in 24 hours
* Glucose-corrected plasma sodium between 135 mmol/l and 145 mmol/l
* Plasma potassium between 3.5 mmol/l and 5 mmol/l
* Written informed consent

Exclusion Criteria:

* Peritoneal dialysis patients
* Signs of volume expansion or contraction
* Congestive heart failure (NYHA ≥2)
* acute illness (infection, congestive heart failure, liver cirrhosis, etc.) requiring hospital admission
* Uncontrolled arterial hypertension
* Hemoglobin ≤8g/dL
* Alcohol abuse
* Malnutrition
* Persons, who are in a dependency/employment relationship with the investigators
* Accommodation in an institution by judicial or administrative order

Where it's running

• Department II of Internal Medicine,University of Cologne
  Cologne, Germany Recruiting

Study contacts

• Principal investigator: Volker Burst, MD — University Hospital of Cologne
• Study coordinator: Volker Burst, MD
• Email: volker.burst@uk-koeln.de
• Phone: +49 221 478 86285

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• Evaluating electrolyte balance in hyponatremia treatment

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  Recruiting University of Cologne · Cologne · NCT05692726

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.