Dialysis method comparison for people aged 85 and older
Official title: HemoDiafiltration Versus HemoDialysis in OLDER People: a Randomized, Multicenter, Crossover, Pragmatic Clinical Trial
Run by AUB Santé · NCT07278973 · Data updated 2026-11-12
This test will compare hemodiafiltration and high-flux hemodialysis to see which gives shorter recovery time and less fatigue for people aged 85 and older.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 85 Years and up |
| Sex | All |
| Enrollment | 62 (estimated) |
| Sponsor | AUB Santé Academic / other |
| Locations | 4 sites (Bretagne and 3 other locations) |
| Status | Recruiting |
| Started | February 19, 2026 |
| Main results expected | December 19, 2026 |
| Study ends | December 19, 2026 |
| Registry record updated | February 23, 2026 |
| Trial ID | NCT07278973 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 85 or older who have end-stage kidney failure, have been on maintenance hemodialysis for more than three months, can attend thrice-weekly 3.5–4 hour sessions, have reliable vascular access, and can provide informed consent in French.
✕Probably not a fit
Patients who are terminally ill, have active cancer, significant cognitive impairment, are hospitalized at enrollment, cannot speak French, or who are younger than 85 are unlikely to benefit from or be eligible for this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, multicenter crossover trial enrolls patients aged 85 and older who are on maintenance hemodialysis and assigns them to two 3-month periods of either hemodiafiltration (HDF) or high-flux hemodialysis (HD) with a two-week low-flux washout between periods. Each participant serves as their own control, with sequence randomized 1:1 and treatments unblinded. Primary outcome is dialysis recovery time, and secondary outcomes include general fatigue and patient-reported symptoms collected during the treatment periods. The aim is to determine which commonly used dialysis modality leads to faster recovery and better quality of life in very old patients.
Why it matters
Potential benefit: If successful, the results could show which dialysis method helps very old patients recover faster and feel less fatigued after treatment.
How similar studies have gone: Previous studies found HDF improved survival in younger populations (mean age ~58), but earlier work by these investigators suggested HDF may prolong recovery time in older patients, so evidence in very old adults is mixed and inconclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed and dated informed consent * Age \>84 years * Diagnosed with kidney failure * On maintenance hemodialysis \>3months * Willing to have a dialysis session of 3.5 to 4-hour duration, three times a week * Has a reliable vascular access * Is covered by the health insurance Exclusion Criteria: * Patients with cognitive impairment (assessed with a mini-test if needed) * Hospitalized at inclusion * Have difficulties with French speaking * Terminally ill with life expectancy\<3 months * With active cancer
Where it's running
-
AUB Santé
Bretagne, France Recruiting -
Aider
Grabels, France Recruiting -
Echo
Le Mans, France Recruiting -
Aura Paris
Paris, France Recruiting
Study contacts
- Study coordinator: Mabel AOUN, M.D., M.P.H.
- Email: aounmabel@yahoo.fr
- Phone: +33174743551
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Cooling During Inpatient Rehab for People with MS
This trial tests whether wearing a cooling vest during intensive training can reduce fatigue and improve walking, strength, balance, and cognition in people with multiple sclerosis during a 3-week inpatient rehab stay.
-
Graded Cognitive Load and How It Affects Mobility in Older Adults
This study tests how different levels of mental demand during movement affect how well people aged 60 and up can walk and move safely.
-
Bioimpedance Spectroscopy for Fluid Changes in Hemodialysis Patients
This study tests whether raw bioimpedance data can help doctors gauge fluid changes in people on hemodialysis and guides fluid removal decisions.
-
Nurse-led dialysis self-management program for distress in adults on hemodialysis
A nurse-led program helps adults on hemodialysis see if structured self-management support reduces dialysis-related distress compared to routine care.
-
Repeated brief limb ischemia to see its effect on blood pressure and inflammation in people with kidney disease
This study tests whether short, repeated episodes of limb ischemia can influence blood pressure, heart rate, and inflammation in adults with chronic kidney disease who may be on hemodialysis.
-
Collagen and omega-3 supplements in middle-aged women
This study tests whether taking collagen and omega-3s together improves joint pain, fatigue, sleep, and overall wellbeing in healthy women aged 35–65 compared with a placebo over 8 weeks.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.