Clinical trial Recruiting at 1 site Interventional Ages 0 to 6

Diagnosing vesicoureteric reflux in children using advanced imaging techniques

Official title: Diagnosing Vesicoureteric Reflux in Children by Direct Isotope Cystography and Contrast Enhanced Voiding Ultrasonography

Run by Turku University Hospital · NCT06138080 · Data updated 2026-11-12

This study tests if a new imaging technique called CEVUS is better than the traditional method for diagnosing vesicoureteric reflux in young children who have had multiple urinary tract infections.

Quick facts

Study typeInterventional
Ages0 Years to 6 Years
SexAll
Enrollment100 (estimated)
SponsorTurku University Hospital
Government
Locations1 site (Turku)
StatusRecruiting
StartedMay 15, 2022
Main results expectedMay 15, 2030
Study endsMay 1, 2031
Registry record updatedNovember 18, 2023
Trial IDNCT06138080 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are children under six years old who have had at least two culture-positive urinary tract infections.

Probably not a fit

Patients with abnormal bladder function or posterior ureteral valves will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of contrast enhanced voiding ultrasonography (CEVUS) compared to direct isotope cystography for diagnosing vesicoureteric reflux (VUR) in children under six years old. The researchers will recruit 100 pediatric patients who have experienced at least two culture-positive urinary tract infections. Both imaging techniques will be performed on the same day by blinded specialists to ensure unbiased results. The goal is to identify a safer and more accurate method for diagnosing and classifying VUR.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic accuracy for vesicoureteric reflux in children, minimizing the risks associated with current imaging methods.

How similar studies have gone: While there have been studies on imaging techniques for VUR, this specific comparison of CEVUS and direct isotope cystography is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* under 6 years old patients who have had at least 2 culture positive urinary tract infections

Exclusion Criteria:

* abnormal bladder function
* posterior uretral valves

Where it's running

  • Turku University hospital
    Turku, Finland
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.