Dexmedetomidine's effects on blood pressure during intubation in hypertensive patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of dexmedetomidine, an alpha-2 adrenergic agonist, on the hemodynamic responses of hypertensive patients undergoing endotracheal intubation. The study aims to assess how dexmedetomidine can reduce anxiety, improve intubating conditions, and attenuate hemodynamic responses such as tachycardia and hypertension during the procedure. Participants will be divided into two groups: one receiving dexmedetomidine and the other receiving a placebo. The trial will focus on patients aged over 60 with a history of hypertension who are scheduled for elective surgeries under general anesthesia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA Grade II
* Age \> 60 years
* Elective surgical procedures under GA.
* All patients with a diagnosis of hypertension for 6 months or more and undergoing treatment with antihypertensive medications.

Exclusion Criteria:

* Patient refusal
* ASA Grade III and IV
* Severely Hypovolemic state
* Emergency surgeries
* Body weight more than 20% of ideal body weight.
* Patients with known or unanticipated difficult intubation and those requiring more than 15 sec or two attempts at laryngoscopy
* Allergic to dexmedetomidine
* Non complaint hypertensive patients
* Patients with uncontrolled hypertension.

Where it's running

• Liaquat National Hospital and Medical College
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Principal investigator: Warisha ismail Dr Warisha ismail — Liaquat National Hospital and Medical College
• Study coordinator: Warisha Ismail Dr Warisha Ismail
• Email: khanveera97@gmail.com
• Phone: +92 3046878028

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.