Dexmedetomidine's effects on blood pressure during intubation in hypertensive patients
Title: the Effects of Dexmedetomidine on Hemodynamic Responses to Endotracheal Intubation in Hypertensive Patients Undergoing Surgery
This study tests if giving dexmedetomidine can help lower blood pressure and anxiety in older patients with high blood pressure during intubation for surgery.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Liaquat National Hospital & Medical College Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT06712186 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of dexmedetomidine, an alpha-2 adrenergic agonist, on the hemodynamic responses of hypertensive patients undergoing endotracheal intubation. The study aims to assess how dexmedetomidine can reduce anxiety, improve intubating conditions, and attenuate hemodynamic responses such as tachycardia and hypertension during the procedure. Participants will be divided into two groups: one receiving dexmedetomidine and the other receiving a placebo. The trial will focus on patients aged over 60 with a history of hypertension who are scheduled for elective surgeries under general anesthesia.
Who should consider this trial
Good fit: Ideal candidates are hypertensive patients over 60 years old undergoing elective surgical procedures under general anesthesia.
Not a fit: Patients with uncontrolled hypertension or those requiring emergency surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to safer intubation practices for hypertensive patients, reducing the risk of serious complications.
How similar studies have performed: Other studies have shown promising results with dexmedetomidine in similar contexts, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA Grade II * Age \> 60 years * Elective surgical procedures under GA. * All patients with a diagnosis of hypertension for 6 months or more and undergoing treatment with antihypertensive medications. Exclusion Criteria: * Patient refusal * ASA Grade III and IV * Severely Hypovolemic state * Emergency surgeries * Body weight more than 20% of ideal body weight. * Patients with known or unanticipated difficult intubation and those requiring more than 15 sec or two attempts at laryngoscopy * Allergic to dexmedetomidine * Non complaint hypertensive patients * Patients with uncontrolled hypertension.
Where this trial is running
Karachi, Sindh
- Liaquat National Hospital and Medical College — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Principal investigator: Warisha ismail Dr Warisha ismail — Liaquat National Hospital and Medical College
- Study coordinator: Warisha Ismail Dr Warisha Ismail
- Email: khanveera97@gmail.com
- Phone: +92 3046878028
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.