Dexmedetomidine to improve waking and reduce coughing after thyroid surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for elective thyroidectomy under general anesthesia will be randomized to receive either a perioperative dexmedetomidine regimen (loading dose before induction and continuous infusion during surgery) plus standard balanced anesthesia or standard anesthesia alone. Standardized anesthetic induction, maintenance, and postoperative care protocols will be used to reduce variability. Key outcomes include intraoperative anesthetic and opioid consumption, coughing at extubation, emergence agitation, hemodynamic responses, postoperative nausea and vomiting, and bleeding-related complications. The study is a randomized, controlled, phase 4 trial conducted at Bach Mai Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-65 years.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Scheduled for elective thyroid surgery (thyroidectomy) under general anesthesia with endotracheal intubation.
* Able to understand the study procedures and provide written informed consent.

Exclusion Criteria:

* Known hypersensitivity or contraindication to dexmedetomidine or study-related medications.
* Clinically significant cardiac conduction abnormality or arrhythmia (e.g., second- or third-degree atrioventricular block without a pacemaker), severe bradyarrhythmia, or unstable cardiovascular disease.
* Severe hepatic dysfunction or severe renal failure.
* Pregnancy or breastfeeding.
* Planned postoperative ICU admission or postoperative deterioration requiring ICU admission.
* Major intraoperative complications (e.g., major bleeding requiring urgent hemostatic intervention, tracheal or esophageal injury, or recurrent laryngeal nerve injury identified intraoperatively).
* Any condition that, in the investigator's judgment, would interfere with outcome assessment or increase risk (e.g., inability to reliably report pain scores or complete QoR-15).

Where it's running

• Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital
  Hanoi, Vietnam Recruiting

Study contacts

• Principal investigator: Thang Toan Nguyen, MD, PhD, Assoc Prof — Bach Mai Hospital, Hanoi, Vietnam.
• Study coordinator: Thang Toan Nguyen, MD, PhD, Assoc Prof
• Email: nguyentoanthang@hmu.edu.vn
• Phone: +084916874795

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postoperative outcomes after thyroidectomy: ERAS vs standard care

  This study tests whether an enhanced recovery after surgery (ERAS) protocol helps adults 18–60 undergoing thyroidectomy recover faster and leave the hospital sooner compared with a local non-ERAS regimen.

  Recruiting Allied Hospital Faisalabad · Faisalabad, Punjab Province · NCT07915960

• ETHY-001 safety and activity in Thyroid Eye Disease (TED)

  This study tests ETHY-001 versus placebo to see if it is safe, tolerable, and shows activity in people with thyroid eye disease.

  Recruiting at 2 sites Phase 1 Ethyreal Bio, Inc. · Orland Park, Illinois and 2 other locations · NCT07885605

• Role of LH and hCG in adults being evaluated for endocrine disorders

  This study looks at whether levels of luteinizing hormone (LH) and hCG in adults undergoing endocrine evaluation relate to their disease presence and outcomes.

  Recruiting Copenhagen University Hospital at Herlev · Herlev · NCT07824102

• WeChat-supported neck exercises after thyroidectomy

  A telehealth program using a WeChat mini program tests if guided neck exercises after thyroid surgery help early recovery and quality of life.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT07707401

• NIRAF-guided identification of parathyroids during thyroidectomy

  A wearable near-infrared autofluorescence device is being tested to help surgeons find and protect the parathyroid glands during thyroid surgery in adults.

  Recruiting Ss. Cyril and Methodius University of Skopje · Skopje · NCT07617584

• Cold (non-thermal) plasma to improve healing and reduce complications after thyroid removal

  This will test whether applying helium-based non-thermal (cold) plasma during total thyroidectomy helps wounds heal faster and reduces pain, inflammation, and infections in adults having their thyroid removed.

  Recruiting National Institute of Nuclear Research - Mexico · Ocoyoacac, State of Mexico · NCT07382973

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.