Determining the best LDL cholesterol levels for small vessel occlusion stroke prevention
Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke (SVO70)
This study is testing the best cholesterol levels and treatments for people who have had small vessel occlusion strokes to see how they can prevent more strokes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 4016 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 46 sites (Ansan and 45 other locations) |
| Trial ID | NCT06649240 on ClinicalTrials.gov |
What this trial studies
This study aims to establish optimal low-density lipoprotein (LDL) cholesterol targets specifically for patients who have experienced small vessel occlusion (SVO) strokes. It will compare the effects of intensive versus standard lipid-lowering therapies, including statins and other medications, on secondary prevention of ischemic strokes. By focusing on a specific subtype of stroke, the study seeks to fill a gap in current guidelines and improve patient outcomes through tailored cholesterol management. Participants will be recruited from multiple centers and will undergo rigorous screening to ensure eligibility based on defined criteria.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 19 years or older who have had a confirmed small vessel occlusive infarction within the last 180 days.
Not a fit: Patients requiring intensive LDL cholesterol management for other conditions or those contraindicated for statin use may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved secondary prevention strategies for patients with small vessel occlusion strokes, potentially reducing the risk of future strokes.
How similar studies have performed: While there have been studies on LDL cholesterol management in general, this specific focus on small vessel occlusion stroke is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 19 years or older 2. Patients with objectively confirmed small vessel occlusive infarctions in the subcortical or brainstem regions, identified through neuroimaging (MRI or CT) 3. Patients with a history of symptomatic ischemic stroke caused by the lesion described in 2), occurring within 180 days prior to enrollment 4. Patients or guardians who agree to the study protocol and sign with informed consent Exclusion Criteria: 1. Patients requiring intensive LDL cholesterol management (LDL-C \<70 mg/dL) due to another condition, with LDL cholesterol targets specified in the guidelines for that condition 2. Patients contraindicated for statin use (e.g., active liver disease, serum transaminase levels elevated more than three times the normal limit, muscle disorders, hypersensitivity to statins, or taking medications contraindicated for use with statins) 3. Women who are pregnant, breastfeeding, or intending to become pregnant during the study period 4. Deemed unsuitable for participation in the study for more than four years, as per the investigators' discretion
Where this trial is running
Ansan and 45 other locations
- Korea University Ansan Hospital — Ansan, South Korea (Recruiting)
- Hallym University Sacred Heart Hospital — Anyang, South Korea (Recruiting)
- Pusan National University Hospital — Busan, South Korea (Recruiting)
- Gyeongsang National University Changwon Hospital — Changwon, South Korea (Recruiting)
- Samsung Changwon Hospital — Changwon, South Korea (Recruiting)
- Chungbuk National University Hospital — Cheongju-si, South Korea (Recruiting)
- Hallym University Chuncheon Sacred Heart Hospital — Chuncheon, South Korea (Recruiting)
- Kangwon National University Hospital — Chuncheon, South Korea (Recruiting)
- Daegu Catholic University Medical Center — Daegu, South Korea (Recruiting)
- Keimyung University Dongsan Medical Center — Daegu, South Korea (Recruiting)
- Kyungpook National University Chilgok Hospital — Daegu, South Korea (Recruiting)
- Kyungpook National University Hospital — Daegu, South Korea (Recruiting)
- Chungnam National University Hospital — Daejeon, South Korea (Recruiting)
- Daejeon Eulji Medical Center — Daejeon, South Korea (Recruiting)
- Dongguk University Ilsan Hospital — Goyang, South Korea (Recruiting)
- Ilsan Paik Hospital — Goyang, South Korea (Recruiting)
- National Health Insurance Service Ilsan Hospital — Goyang, South Korea (Recruiting)
- Hanyang University Guri Hospital — Guri-si, South Korea (Recruiting)
- Chonnam National University Hospital — Gwangju, South Korea (Recruiting)
- Chosun University Hospital — Gwangju, South Korea (Recruiting)
- Chung-Ang University Gwangmyeong Hospital — Gwangmyeong, South Korea (Recruiting)
- Dongtan Sacred Heart Hospital — Hwaseong, South Korea (Recruiting)
- Wonkwang University Hospital — Iksan, South Korea (Recruiting)
- Gachon University Gil Medical Center — Incheon, South Korea (Recruiting)
- Inha University Hospital — Incheon, South Korea (Recruiting)
- International St. Mary's Hospital — Incheon, South Korea (Recruiting)
- Jeju National University Hospital — Jeju City, South Korea (Recruiting)
- Seoul National University Bundang Hospital — Seongnam, South Korea (Recruiting)
- Asan Medical Center — Seoul, South Korea (Not_yet_recruiting)
- Chung-Ang University Hospital — Seoul, South Korea (Recruiting)
- Ewha Womans University Mokdong Hospital — Seoul, South Korea (Recruiting)
- Ewha Womans University Seoul Hospital — Seoul, South Korea (Recruiting)
- Gangnam Severance Hospital — Seoul, South Korea (Recruiting)
- Hallym University Kangdong Sacred Heart Hospital — Seoul, South Korea (Recruiting)
- Hanyang University Seoul Hospital — Seoul, South Korea (Recruiting)
- Konkuk University Medical Center — Seoul, South Korea (Recruiting)
- Korea University Anam Hospital — Seoul, South Korea (Recruiting)
- Kyung Hee University Medical Center — Seoul, South Korea (Recruiting)
- National Medical Center — Seoul, South Korea (Recruiting)
- Nowon Eulji Medical Center — Seoul, South Korea (Recruiting)
- Samsung Medical Center — Seoul, South Korea (Recruiting)
- Seoul Metropolitan Government-Seoul National University Boramae Medical Center — Seoul, South Korea (Recruiting)
- Seoul National University Hospital — Seoul, South Korea (Recruiting)
- Severance Hospital — Seoul, South Korea (Recruiting)
- Yeouido St. Mary's Hospital — Seoul, South Korea (Recruiting)
- Yongin Severance Hospital — Yŏngin, South Korea (Recruiting)
Study contacts
- Principal investigator: Seung-Hoon Lee, MD, PhD — Seoul National University Hospital
- Study coordinator: Wookjin Yang, MD, PhD
- Email: ywj_2002@naver.com
- Phone: +82-70-4352-2482
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.