Detecting thalamus seizures using a Percept deep brain stimulator

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a two-phase feasibility effort enrolling five adults with drug‑resistant epilepsy who already have a Medtronic Percept deep brain stimulator implanted. In Phase 1 participants undergo inpatient epilepsy monitoring unit (video‑EEG) while concurrent thalamic recordings from the Percept device are collected to calculate sensitivity, specificity, and false alarm rate. In Phase 2 the device is used for chronic ambulatory thalamic sensing and DBS stimulation in the outpatient setting. The study is conducted at Mayo Clinic in Rochester and focuses on validating thalamic seizure detection against the gold-standard inpatient video‑EEG.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Participants must meet all of the inclusion criteria to participate in this study:

* 18 years of age and older.
* Implanted with a clinical DBS system for epilepsy with brain recording capabilities (Medtronic Percept™ DBS).
* Subject or legally authorized representative is able to understand study procedures and to comply with them for the entire length of the study.

Exclusion Criteria:

All candidates meeting any of the exclusion criteria at baseline will be excluded from study participation:

* Health status or any clinical conditions (e.g., life expectancy, co-existing disease) that, in the opinion of the site investigator, would pose undue risk to undergo epilepsy monitoring unit evaluation for the purpose of seizure characterization.
* Women will verify not pregnant, and if applicable, have urine pregnancy test.
* Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
* Inability or unwillingness of individual or legal guardian/representative to give written informed consent.

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Nicholas Gregg — Mayo Clinic
• Study coordinator: Karla Crockett
• Email: crockett.karla@mayo.edu
• Phone: 507-538-4880

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.