Dentine Adhesive with Strontium-doped Bioactive Glass-Ceramic for Sensitivity Relief
Official title: Dentine Hypersensitivity Treatment Using Strontium-doped Bioactive Glass-ceramic-filled Dentine Adhesive: a Randomized Double-blind Controlled Clinical Trial
Run by The University of Hong Kong · NCT07628712 · Data updated 2026-11-12
This trial tests whether a strontium-doped bioactive glass-ceramic filled dentine adhesive can better relieve dentine hypersensitivity than a regular dentine adhesive in adults with sensitive teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 69 Years |
| Sex | All |
| Enrollment | 142 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 2 sites (Hong Kong and 1 other locations) |
| Status | Recruiting |
| Started | June 16, 2026 |
| Main results expected | May 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT07628712 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–69 years with cervical dentine hypersensitivity for at least 1 month and at least one hypersensitive tooth suitable for adhesive treatment.
✕Probably not a fit
Participants with hypersensitivity not responsive to the adhesive or with exclusion criteria may not experience a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 18–69 with cervical dentine hypersensitivity will be randomly assigned to receive either SBGC-filled dentine adhesive or a standard dentine adhesive on exposed root surfaces. Sensitivity will be measured with an air blast and a 0–10 Sensitivity Score at baseline, immediately after application, and at 1, 3, and 6 months. The study uses a 1:1 randomization and follows participants at multiple follow-ups to compare pain reduction between groups. Exclusion criteria include extensive dental disease, recent desensitizing treatment, and conditions that could affect pain perception. The lead sponsor is The University of Hong Kong, with study sites at The Prince Philip Dental Hospital and HKU facilities.
Why it matters
Potential benefit: If successful, SBGC-filled adhesive could provide greater and longer-lasting relief from dentine hypersensitivity.
How similar studies have gone: Previous research on bioactive glass-ceramics shows potential for dentine treatment, but results vary and this exact SBGC-filled adhesive approach is being tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * individuals who experienced cervical dentine sensitivity for 1 month or more Exclusion Criteria: * 1\) \<20 teeth; 2) teeth with poor oral hygiene, severe periodontal conditions, with caries, faulty restorations, dentine exposure at the occlusal surface, covered by prosthetics or orthodontic appliances, or undergoing endodontic treatment; 3) currently using or have used any desensitizing agents in the past 3 months; or have undergone restorative treatment on the sensitive tooth; 4) with a severe medical condition or in chronic use of a medication that could have interfered with the perception of pain or any condition/medication that causes xerostomia
Where it's running
-
Clinical Research Center, the Prince Philips Dental Hospital
Hong Kong, Hong Kong Recruiting -
the University of Hong Kong
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Katherine CM LEUNG, BDS MDS PhD — The University of Hong Kong
- Study coordinator: Katherine CM LEUNG, BDS MDS PhD
- Email: kcmleung@hku.hk
- Phone: 852-28590307
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.