Delayed versus Rapid Sequence Induction for emergency endotracheal intubation in adults with medical illness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a feasibility interventional comparison of two induction approaches for emergency endotracheal intubation in critically ill adults in an ICU setting. The trial will apply either Delayed Sequence Induction or a Modified Rapid Sequence Induction and collect routinely recorded ICU outcomes plus a single 90‑day phone follow-up. The main goals are to see if Delayed Sequence Induction reduces severe hemodynamic complications and to refine which outcome measures best capture those complications with minimal bias. No additional diagnostic tests are required beyond standard ICU care, and common exclusions include CPR, unstable return of spontaneous circulation, known drug allergies/contraindications, anticipated need for awake fiberoptic intubation, and pregnancy or breastfeeding.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients 18 years or older in need of emergency endotracheal intubation in the following 60 minutes.
* The planned operateur routinely performs endotracheal intubation in critically ill patients.

Exclusion Criteria:

* Endotracheal Intubation performed during cardiopulmonary resuscitation or during "unstable ROSC", defined as Norepinephrine or Epinephrine dose \> 0,5 µg/kgKG/min after return of spontaneous circulation.
* Participation in the study is not warranted because of increased risk for the patient or otherwise not justifiable (e.g. active oral bleeding).
* Known allergy against Ketamine, Esketamine, Midazolam or Rocuronium.
* Known contraindication against Ketamine, Esketamine Midazolam or Rocuronium.
* Known or anticipated difficult airway with indication for awake fiberoptic intubation.
* Women with known pregnancy or breastfeeding.

Where it's running

• Interdisciplinary Medical ICU, Leipzig Medical University Center
  Leipzig, Saxony, Germany Recruiting

Study contacts

• Principal investigator: Anton J Pelka — Interdisciplinary Medical ICU, Leipzig Medical University Center
• Study coordinator: Anton J Pelka
• Email: anton.pelka@medizin.uni-leipzig.de
• Phone: +49 341 97 12700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.