Dairy Choline Availability: Is WPPC a match for eggs in postmenopausal women?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare choline bioavailability and metabolism when consumed as WPPC vs. whole egg powder in a chocolate smoothie. The study focuses on how the body uses choline and whether WPPC can match eggs as a source of choline in postmenopausal women. Participants will provide blood, urine, and fecal samples at baseline and after 10 days of intervention to assess metabolic differences. The trial is conducted at the University of Wisconsin–Madison and involves a short dietary intervention with two 4-day food diaries. The goal is to improve understanding of WPPC's contribution to nutritional needs in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages between 51 and 70
* Is currently post-menopausal (Post-menopausal is a term used to describe the time in a woman's life after she has gone through menopause. This usually happens between the ages of 45 and 55. Menopause is when a woman's menstrual periods stop permanently (at least 12 months))
* Not allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds.)
* Had stable body weight (± 5%) for the past 6 months
* Free from cancer
* Did not have weight loss surgery, colon surgery
* Do not have chronic kidney diseases
* Do not have malabsorption towards fat and dairy products
* Willing to complete health surveys
* Willing to complete two 4-day food diaries
* Willing to consume the intervention smoothies
* Willing to provide blood, urine, fecal samples at baseline and after 10 days of intervention

Exclusion Criteria:

* On weight loss/weight gain diets
* Diagnosed with fat malabsorption
* Undergoing weight loss surgery
* Diagnosed with chronic kidney diseases
* Allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, chocolate, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds, banana, strawberry, raspberry, blackberry, blueberry.)
* Regularly using antibiotics or probiotics or prebiotics
* Regularly using weight-loss drugs (GLP-1, Orlistat, Cetilistat, etc.)
* Regularly using laxatives
* Unable to avoid strenuous exercise during the study (\>4 h vigorous exercise per day)

Where it's running

• University of Wisconsin - Madison
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Bradley Bolling, PhD — University of Wisconsin, Madison
• Study coordinator: Kevin Shih
• Email: sshih22@wisc.edu
• Phone: 919-338-9453

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.