Cryoneurolysis vs. radiofrequency for knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares cryoneurolysis to pulsed and cooled radiofrequency procedures for adults with knee osteoarthritis whose pain persists despite at least six months of conservative therapy. The trial focuses on pain reduction and safety as patients receive one of the nerve-targeting treatments designed to provide longer-lasting relief without drugs. Participants are adults with refractory knee OA who meet specific eligibility criteria and do not have contraindications such as infections, tumors, or implanted cardiac devices. Outcomes of interest include changes in knee pain and functional status after the procedures. The study is led by Tanta University, with the Faculty of Medicine serving as the site.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults with a clinical diagnosis of refractory knee OA who suffered from refractory knee pain (patients who had failed conservative medical and physical therapy for 6 months .

Exclusion Criteria:

1. Patients with OA show improvement in pain after conservative medical and physical therapy.
2. Patients evaluated by an orthopedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.
3. Patients with allergies to local anesthetics.
4. patients on anticoagulation therapy, who were not permitted to stop anticoagulation.
5. Patients with knee tumors.
6. Patients with acute infections.
7. Patients with implanted cardiac devices.
8. Pregnant patients.

Where it's running

• Faculty of medicine, Tanta University
  Tanta, Egypt Recruiting

Study contacts

• Study coordinator: Aliaa Mamdouh Abdelaziz Farag, MD
• Email: aliaa.mamdouh@med.tanta.edu.eg
• Phone: +201069468486

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.