Cryo-freezing of chest nerves to reduce pain after double lung transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

During double lung transplant surgery, surgeons may use a cold-therapy probe (Atricure CryoSPHERE MAX) to gently freeze the intercostal nerves near the incision to reduce pain for several days. Patients who receive intraoperative cryoanalgesia will be compared with patients receiving usual care without the device across several hospitals, with about 148 adults expected to enroll. The main goal is to see whether the cryotherapy group uses at least 25% fewer opioids in the first 10 days after surgery, and secondary outcomes include need for additional pain treatments like epidurals, average daily pain scores, and ICU length of stay. All participants will be followed for one year to monitor recovery and any long-term effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥18 years of age
* Undergoing double lung transplantation via bilateral thoracotomies or clamshell incision

Exclusion Criteria:

* Multi-organ transplant recipients
* Redo lung transplant recipients

Where it's running

• University of California Los Angeles
  Los Angeles, California, United States Recruiting
• University of California San Francisco
  San Francisco, California, United States Not yet recruiting
• Baylor University
  Waco, Texas, United States Not yet recruiting

Study contacts

• Principal investigator: Abbas Ardehali, MD — University of California, Los Angeles
• Study coordinator: Steven Stokes
• Email: sstokes@mednet.ucla.edu
• Phone: 310-206-7436

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.