Creating stem cells from patients with neurological diseases
Official title: Derivation of Induced Pluripotent Stem Cells from Somatic Cells Donated by Patients with Neurological Diseases for the Study of the Pathogenesis of the Disorders and Development of Novel Therapies
Run by Hadassah Medical Organization · NCT00874783 · Data updated 2026-11-12
This study is trying to create special stem cells from patients with neurological diseases to help researchers understand these conditions better and find new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Hadassah Medical Organization Academic / other |
| Locations | 1 site (Jerusalem, Israel) |
| Status | Recruiting |
| Started | April 2009 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | March 4, 2025 |
| Trial ID | NCT00874783 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with neurodegenerative disorders like ALS, Parkinson's, and Alzheimer's, as well as healthy donors undergoing surgery.
✕Probably not a fit
Patients who are not undergoing surgery or are not willing to donate hair or skin samples may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on developing induced pluripotent stem (iPS) cells from the somatic cells of patients suffering from various neurodegenerative disorders. By reprogramming human fibroblasts or other somatic cells, the researchers aim to create iPS cells that can model diseases and aid in drug discovery. The iPS cells will be used primarily for basic research and understanding disease mechanisms, rather than for immediate transplantation therapies. The project seeks to explore the similarities between iPS cells and human embryonic stem cells to advance research in regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to new models for understanding neurodegenerative diseases and developing targeted therapies.
How similar studies have gone: Other studies have shown promise in using iPS cells for disease modeling, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Donors suffering from different (specified) neurodegenerative disorders scheduled to undergo surgery for medical reasons or will donate a single or a few hairs--to be removed intact from the scull or other areas in the body. * Healthy donors scheduled to undergo surgery for medical reasons or will donate a single or a few hairs--to be removed intact from the scull or other areas in the body. Exclusion Criteria: * None
Where it's running
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Hadassah Ein Kerem
Jerusalem, Israel, Israel Recruiting
Study contacts
- Principal investigator: Benjamin E Reubinoff, MD, PhD — Hadassah Medical Organization
- Study coordinator: Benjamin E. Reubinoff, MD PhD
- Email: benjaminr@ekmd.huji.ac.il
- Phone: 011-972-2-677-4569
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.