Cortical Excitability and DLPFC Structure in Healthy Adults Using TMS, EEG, and High-Field MRI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy adults will receive repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex while EEG and high-field MRI measurements are recorded to explore links between cortical excitability and prefrontal cytoarchitectonics. The study builds on prior small-sample findings suggesting EEG and brain structure patterns may correspond to response tendencies. It uses TMS stimulation with concurrent neuroimaging while monitoring safety and comfort. No disease treatment is being tested in this nonpatient population. The aim is to better understand brain–structure–function relationships in the DLPFC under TMS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* People aged 18 to 35
* People affiliated with a social security scheme or beneficiary of such a scheme
* People who have signed the informed consent
* Right-handed people
* People with a body mass index between 18 and 26
* People able to abstain from alcohol for 24 hours prior to the experiment
* People able to remain perfectly still for 15 minutes straight, and able to have reduced mobility for 3 hours
* People able to of not using narcotics (marijuana, cocaine, ecstasy, MDMA, ketamine, etc.) during the 15 days preceeding the experiment.
* Conducting a pregnancy test before inclusion for women of childbearing age and when the research is conducted over a long period, at a frequency adapted to the gaze of the research acts
* Effective contraception for women of childbearing potential

Exclusion Criteria:

* Pregnant, parturient, or breastfeeding
* Protected adults
* Minors
* People staying in a healthcare or social institution
* People in an emergency situation
* People deprived of their liberty
* People with the usual contraindications to MRI

  * Ferromagnetic surgical clips, ocular implants, metallic foreign bodies intraocularly or in the nervous system, implants or metallic objects susceptible to concentrate the radio frequency field, cochlear implants, brain stimulator or cardiac pacemaker, presence of a craniotomy scar, agitation
  * Claustrophobia
  * Large, black tattoo close to the orofacial area
* People not wishing to be informed of abnormalities discovered at the MRI
* People with a history of epilepsy or suffering from epilepsy
* Individuals whose parents, children, siblings, or parents have a history of epilepsy
* People with known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction
* Staff with a hierarchical link to the investigators

Where it's running

• Hôpital la Timone
  Marseille, France Recruiting

Study contacts

• Study coordinator: Pr Maxime GUYE
• Email: Maxime.GUYE@ap-hm.fr
• Phone: +33 4 91 32 48 01

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using brain activity markers to predict response to accelerated iTBS for OCD

  This will try accelerated intermittent Theta Burst Stimulation (iTBS) targeting the dmPFC and ACC to reduce symptoms in adults (18–65) with treatment‑resistant OCD and to find brain activity markers that predict who benefits.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakirkoy · NCT07561528

• 12-week ETAS® supplement for thinking, mood, sleep, and brain health in older adults

  This 12-week test will see if taking 1500 mg ETAS® daily helps thinking, mood, sleep, and brain scan measures in healthy adults aged 60–80 with mild cognitive complaints.

  Recruiting University of Reading · Reading, Berkshire · NCT07550140

• Targeted brain mapping and magnetic stimulation to speed up actions

  This project will test whether using EEG and fNIRS to guide targeted magnetic brain stimulation (TMS/iTBS) can speed up action in healthy adults and in people who had a hemispheric stroke that spared key prefrontal areas.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT07468032

• MRI versus ultrasound for early liver cancer detection, body composition, and decompensation risk in cirrhosis

  This project will test whether abbreviated MRI or ultrasound is better at finding early liver cancer and measuring muscle and fat in adults with cirrhosis.

  Recruiting Linkoeping University · Linköping, Select A State Or Province · NCT07291141

• iWalk: an eight-week mindfulness walking program to build resilience

  This program tests whether an eight-week guided walking meditation can help adults with neurodegenerative conditions (like MS) improve resilience, mood, and self-regulation.

  Recruiting University of Illinois at Urbana-Champaign · Urbana, Illinois · NCT07285954

• Home-based brain stimulation versus duloxetine for fibromyalgia

  This trial will test whether home-based transcranial direct current stimulation (tDCS) works as well as duloxetine 60 mg for women with moderate-to-severe fibromyalgia when combined with exercise and pain education.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07203339

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.