12-week ETAS® supplement for thinking, mood, sleep, and brain health in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blind, randomized, placebo-controlled parallel trial in 60 healthy older adults (60–80 years) with mild to moderate subjective cognitive complaints. Participants will take capsules containing 1500 mg ETAS® or placebo daily for 12 weeks, with cognitive, affective, sleep, metabolic, inflammatory, anthropometric, and blood pressure measures collected before and after supplementation. Brain structure, function, and chemistry will be measured with MRI/fMRI at both time points, and a randomly selected subset of 30 participants (15 per group) will provide stool samples for microbiome analysis at two time points. Individuals taking excluded medications or with diagnosed psychiatric, neurologic, cardiometabolic, or thyroid disorders are not eligible.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aging between 60-80 years old
* Having normal vision and hearing
* Having a body mass index between 18.5 and 30
* Having mild to moderate subjective cognitive complaints

Exclusion Criteria:

* Smoking
* Having food allergies
* Following restrictive and/or unbalanced diets (Appendix 6: Are you vegetarian or vegan? Yes / No; Are you currently on a weight-reducing or other special diet? Yes/No If 'Yes', please give details.)
* Being diagnosed with any psychiatric or neurologic conditions (e.g. schizophrenia, depression, dementia) including eating disorders
* Being diagnosed with any cardiometabolic diseases (including type II diabetes and cardiovascular disease), or hypertension or thrombosis related disorders or suffer from thyroid disease
* Currently taking anticoagulants, antiplatelet medication, antidepressants, proton-pump inhibitors
* Currently consuming prebiotic or probiotic supplements
* Continuous antibiotic use for \> 3 days within 1 month prior to enrolment
* Continuous use of weight-loss drug for \> 1 month before screening
* Having a significant gastrointestinal (GI) condition affecting absorption including (but not limited to) inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end stage renal disease; active cancer, or treatment for any cancer, in last 3 years
* History of claustrophobia
* Fitted with a pacemaker or artificial heart valve
* Have active implants, such as cochlear, ocular, or penile implant
* Experience of metal fragments e.g. shrapnel in your eyes or any other part of your body
* Drug infusion pump installed
* Have any surgically implanted metal in any part of your body, other than dental fillings and crowns (e.g. joint replacement or bone re-construction)
* Have had any surgery that might have involved metal implants
* Current or historical experience of epilepsy
* Have stimulators for nerves, brain or bone installed
* Have an intrauterine contraceptive device installed (IUD)
* Wear transdermal patches containing metal
* Wear a filling, crown, dental post (entirely within the tooth) associated with root canal treatment, retainer, bridge or braces
* For scanning, would need to remove coloured contact lenses, nail polish and makeup.
* Hearing aid wearer
* Body piercings that you cannot or will not remove for the scanning session
* Have tattoos or permanent makeup

Where it's running

• University of Reading, School of Psychology and Clinical Languages
  Reading, Berkshire, United Kingdom Recruiting

Study contacts

• Study coordinator: Piril Hepsomali, PhD
• Email: p.hepsomali@reading.ac.uk
• Phone: +44 118 378 5818

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Can the Ronnie Gardiner Method improve thinking and daily function in people with Parkinson’s

  In this 10-week program, adults with Parkinson’s disease will try the Ronnie Gardiner Method to see if it helps thinking, talking, movement, balance, and quality of life.

  Recruiting University Ghent · Ghent, Oost-Vlaanderen · NCT07863219

• Beef-Protein Ready-to-Eat Meals to Support Firefighter Recovery

  This study tests whether beef-based ready-to-eat meals help firefighters recover better after simulated firefighting tasks, compared with plant-based meals.

  Recruiting at 2 sites Sam Houston State University · Fort Worth, Texas and 1 other locations · NCT07822048

• How pork protein affects recovery after simulated firefighting

  This study tests whether pork-based meals help firefighters recover better and perform sooner after hard simulated fire drills, compared with plant-based meals or carbohydrate-focused meals.

  Recruiting at 2 sites Sam Houston State University · Fort Worth, Texas and 1 other locations · NCT07819565

• LpD3.5 Intervention for Gut Health and Cognition in Older Adults with MCI

  In older adults with mild cognitive impairment, this study tests whether daily LpD3.5 capsules can improve gut health and potentially cognition compared with placebo.

  Recruiting Early Phase 1 University of South Florida · Tampa, Florida · NCT07794956

• Ketone and Carbohydrate Supplementation in Endurance Cycling

  This study tests whether adding ketones to a carb plan helps amateur endurance cyclists perform better and think more clearly during long, exhausting rides.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07792876

• Appetite and Thinking Response to a Breakfast Cereal

  This study tests how eating a ready-to-eat breakfast cereal affects appetite and thinking in healthy adults who regularly eat cereal.

  Recruiting General Mills · Minneapolis, Minnesota · NCT07782229

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.