Continuous chest compression to improve lung function in ARDS patients
Evaluation of the Effects of Continuous Anterior Chest Compression on Ventilation/Perfusion Ratios and Hemodynamics in SDRA
NA · Assistance Publique - Hôpitaux de Paris · NCT06699017
This study is testing if a new method of continuous chest compression can help improve lung function in adults with moderate to severe acute respiratory distress syndrome (ARDS).
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Créteil, Creteil) |
| Trial ID | NCT06699017 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of continuous anterior chest compression (CACC) on the ventilation/perfusion ratio and hemodynamics in patients with acute respiratory distress syndrome (ARDS). The hypothesis is that CACC may reduce overdistension of the anterior lung regions while promoting better ventilation in the posterior areas. Participants will be adults aged 18 and older with moderate to severe ARDS, who are sedated and paralyzed. The study aims to assess the potential benefits of this intervention in improving lung function and overall patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with moderate to severe ARDS.
Not a fit: Patients who are pregnant, have certain cardiac devices, or are hemodynamically unstable may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve lung function and reduce mortality in ARDS patients.
How similar studies have performed: While the specific approach of CACC is novel, similar studies exploring mechanical ventilation strategies have shown promise in improving outcomes for ARDS patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * ARDS moderate to severe according to the Berlin criteria * Patient receiving continuous sedation and curarization * Free and informed consent from the patient or family member Exclusion Criteria: * Pregnancy * Adult patient subject to a legal protection measure (tutor, curator, etc.) * Patients with a pacemaker, automatic implantable cardioverter defibrillator, * Contraindications to thoracic belt placement (e.g., thoracic or spinal cord trauma, recent thoracic surgery) * Undrained pneumothorax, bronchopleural fistula * Hemodynamic instability (i.e., use of intravenous fluids of more than 10 mL/kg or vasopressors 2 mg/h of norepinephrine or 0.5 mg/h of epinephrine)
Where this trial is running
Créteil, Creteil
- Henri Mondor hospital — Créteil, Creteil, France (RECRUITING)
Study contacts
- Study coordinator: Labedade
- Email: Pascale.labedade@aphp.fr
- Phone: 0145178506
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Respiratory Distress Syndrome, ARDS, cardiac output, ventilation perfusion ratio