Constraint-induced movement therapy to improve walking after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-blind, randomized, 6-week training comparison that blocks participants by baseline gait speed and randomizes them to either constraint-induced movement therapy (CIMT) plus locomotor training or treadmill training alone. Training is performed three times per week for up to 45 minutes per session as tolerated, with gait assessed three times to measure change. The protocol enrolls a total of 36 participants who meet inclusion criteria and can walk at least 10 meters without physical assistance. Interventions include treadmill-based locomotor training and robotic-assisted components as part of the therapy program.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age between 21 and 75 years;
2. history of unilateral, supratentorial, ischemic or hemorrhagic stroke;
3. no prior stroke;
4. demonstration of impaired walking function (self-selected walking speed ≤ 0.80 m/s);
5. able to stand and walk (\>10 meters) without physical assistance.

Exclusion Criteria:

1. significant cardiorespiratory/metabolic disease;
2. other neurological or orthopedic injury that impairs locomotion;
3. scores on the Mini Mental Status examination \< 24;
4. stroke of the brainstem or cerebellar lesions;
5. uncontrolled hypertension (systolic \> 200 mm Hg, diastolic \> 110 mm Hg);
6. botox injection within 6 months of starting the study.

Where it's running

• Abilitylab
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Ming Wu, PhD — Abilitylab
• Study coordinator: Weena Dee, PT
• Email: wdee@ric.org
• Phone: 312-238-7503

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.