Comparing walking with powered and passive prosthetic knees for amputees
Official title: Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss
Run by Loma Linda University · NCT05831696 · Data updated 2026-11-12
This study tests whether walking with a powered prosthetic knee is easier and more efficient for people with leg amputations compared to using a standard knee.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 12 (estimated) |
| Sponsor | Loma Linda University Academic / other |
| Locations | 1 site (Loma Linda, California) |
| Status | Recruiting |
| Started | February 27, 2023 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | February 4, 2026 |
| Trial ID | NCT05831696 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 18-75 with unilateral transfemoral amputation who have experience using a prosthesis and demonstrate a high level of ambulation potential.
✕Probably not a fit
Patients who have multiple amputations, those who cannot walk at different speeds, or who are less than 180 days post-amputation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research evaluates the metabolic costs associated with walking using a powered microprocessor-controlled knee compared to a standard prosthesis among individuals with transfemoral amputation. Participants will undergo a series of treadmill tests to measure heart rate and metabolic function while using both types of prosthetic knees. The study aims to determine if the powered knee improves walking efficiency in various conditions, including level ground and inclines. Participants will be fitted with a metabolic analyzer and heart rate monitor to collect data during the tests.
Why it matters
Potential benefit: If successful, this study could lead to improved walking efficiency and quality of life for amputees using powered prosthetic knees.
How similar studies have gone: Previous studies have shown promising results with powered prosthetic devices, indicating potential benefits in mobility and metabolic efficiency.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and Females with unilateral knee disarticulation or transfemoral (KD/TF) amputation. * a body mass greater than 49Kg and less than 117Kg * 18-75 years of age * Have an ambulation potential of K3 or K4 * Use a prosthesis daily for walking or sports activities * No less than six months of experience with a prosthesis * No socket issues or changes in the last six weeks * No residual limb pain affecting functional ability. Exclusion Criteria: * Cannot walk at different speeds (MCFL K0-K2) * Limb-loss below the knee or through the hip * More than one amputation. * Uses an assistive device for walking * Uncontrolled edema in leg compartments * Compromised skin of the residual limb or contralateral foot * Are 180 days or less post-amputation * Pregnant (self-reported)
Where it's running
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Loma Linda University
Loma Linda, California, United States Recruiting
Study contacts
- Principal investigator: Michael Davidson, Ph.D. — Loma Linda University Health
- Study coordinator: Michael Davidson, Ph.D.
- Email: mdavidson@llu.edu
- Phone: 9095586516
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Personalizing powered knee prostheses using reinforcement learning
This trial will test whether a computer system called RISE can help clinicians tune powered knee prostheses faster and make them work better for people with above-knee (transfemoral) amputations.
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Neural-controlled powered knee and ankle for people with above-knee amputation.
We will test whether a neural-controlled powered knee or ankle prosthesis helps people with above-knee (transfemoral) amputation walk more naturally and stably in everyday situations.
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How residual limb length relates to strength, balance, and function after transfemoral amputation
This study tests how the length of the missing lower leg segment affects strength, balance, and daily function in adults with a transfemoral amputation.
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Evaluating the Ossur Power Knee for people with above-knee amputations
This study is testing whether the Ossur Power Knee, a high-tech prosthetic knee that helps with movement, works better than a regular prosthetic knee for people with above-knee amputations.
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Improving prosthetic socket fit for veterans with lower limb amputations
This study is testing whether an adjustable prosthetic socket can help veterans with lower limb amputations walk better and feel more comfortable compared to a regular socket.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.