Comparing vegetarian and non-vegetarian diets for preventing hepatic encephalopathy recurrence in cirrhosis patients

Effect of Vegetarian Versus Non Vegetarian Based Diet in the Recurrence of Hepatic Encephalopathy in Patients With Cirrhosis:An Open Label Study

This study is testing whether a vegetarian diet can help prevent future episodes of hepatic encephalopathy in people with cirrhosis compared to a non-vegetarian diet.

Quick facts

• Study type: Observational
• Enrollment: 40 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Sir Ganga Ram Hospital (Academic / other)
• Locations: 1 site (Delhi)
• Trial ID: NCT06328088 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate the impact of vegetarian versus non-vegetarian diets on the recurrence of hepatic encephalopathy (HE) in patients with cirrhosis. It focuses on patients who have recently recovered from an episode of HE, assessing how different protein sources may influence their health outcomes. The study will enroll participants from the outpatient department of Sir Ganga Ram Hospital, where their dietary habits will be monitored and analyzed. The goal is to determine if a vegetable-based diet can help prevent future episodes of HE compared to an animal-based diet.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with a confirmed diagnosis of liver cirrhosis who have recently recovered from an episode of hepatic encephalopathy.

Not a fit: Patients with severe cardiopulmonary disease, hepatocellular carcinoma, or a CTP score of more than 12 may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide dietary recommendations that help reduce the recurrence of hepatic encephalopathy in cirrhosis patients.

How similar studies have performed: While dietary interventions in hepatic encephalopathy have been suggested in case reports, this specific comparison of vegetarian versus non-vegetarian diets is novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

- 1) Age 18 years and older. 2) Confirmed diagnosis of liver cirrhosis. (Diagnosed on the basis of clinical, biochemical, radiological or endoscopic features).

3) Willingness to sign informed consent proforma. 4) Patients who recovered from Hepatic encephalopathy will be enrolled from Out patient Department within 15 days of discharge

Exclusion Criteria:

- 1) Patients with underlying severe cardiopulmonary disease or hepatocellular carcinoma.

2) Patients with CTP score of more than 12 3) Patient not willing for follow up or consent to participate in the study

Where this trial is running

Delhi

• Sir Ganga Ram Hospital — Delhi, India (Recruiting)

Study contacts

• Study coordinator: Praveen Sharma, MD,DM

Conditions Hepatic Encephalopathy; Hepatic encephalopathy; diet; vegetarian; non vegetarian; cirrhosis