Comparing two nerve-block combinations to reduce pain after total knee replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial randomizes patients having total knee arthroplasty under spinal anesthesia to receive a femoral triangle block combined with either a popliteal plexus block (PPB) or a distal IPACK block as part of multimodal analgesia. Postoperative pain scores at rest and with movement, opioid consumption, and early functional outcomes will be recorded to compare analgesic effectiveness. The IPACK involves ultrasound‑guided infiltration between the popliteal artery and the posterior knee capsule and has been linked to lower pain and opioid needs, while PPB is a newer technique targeting posterior knee innervation. The goal is to identify which block combination gives better posterior‑knee pain relief with minimal motor impairment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing total knee arthroplasty under spinal anesthesia
* American Society of Anesthesiologists (ASA) status I-III
* Patients who give informed consent

Exclusion Criteria:

* Patients unable to cooperate
* Kidney disease with GFR \< 50 ml/min
* Daily opioid consumption \> 1 month
* Allergy to local anesthetics
* Neurological problems of the lower extremity
* Contraindications to peripheral nerve blocks

Where it's running

• Karaman Training and Research Hospital, Karaman, Karaman 70200
  Karaman, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Tayfun Et
• Email: drtayfunet@gmail.com
• Phone: +905063670717

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Can robotic-assisted knee replacement with functional alignment improve outcomes vs. standard knee replacement?

  This trial tests whether using the VELYS robotic system during total knee replacement helps patients with knee osteoarthritis feel better and move more comfortably compared with conventional non-robotic surgery.

  Recruiting Golden Jubilee National Hospital · Glasgow, Scotland · NCT07551856

• BETY with intra-articular injections for knee osteoarthritis

  This will try whether adding BETY to intra-articular knee injections reduces pain and improves function in adults with stage 2 or 3 knee osteoarthritis.

  Recruiting Hacettepe University · Ankara, Samanpazarı · NCT07496203

• Home-based leg dexterity training for knee osteoarthritis

  This study will test whether an at-home leg dexterity device can reduce pain and improve function for people aged 40–85 with knee osteoarthritis compared with wobble-board exercises.

  Recruiting Steadman Philippon Research Institute · Vail, Colorado · NCT07397806

• Catheter embolization of small knee arteries to relieve osteoarthritis pain

  This study will try using a catheter procedure to block small arteries around the knee to reduce chronic pain in adults 40–80 with knee osteoarthritis or persistent pain after knee replacement who haven't found enough relief from standard treatments.

  Recruiting Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s. · Ústí nad Labem · NCT07361198

• Adding sensory nerve blocks to local pain injections for total knee replacement

  This trial tests whether adding three sensory nerve blocks to standard local pain injections reduces pain and opioid use after primary unilateral total knee replacement.

  Recruiting Phase 4 Region Skane · Trelleborg · NCT07350252

• Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy for Older Adults with Knee Osteoarthritis

  This trial will test whether applying high-intensity pulsed electromagnetic fields to both the knee and quadriceps reduces pain and improves function more than applying it only to the knee in adults 60 and older with knee osteoarthritis.

  Recruiting Hospital Civil de Guadalajara · Guadalajara, Jalisco · NCT07198750

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.