Comparing two methods for closing midline laparotomy incisions to prevent hernias
Official title: NoPro - Norwegian Hernia Prophylaxis Study: Onlay Mesh Versus Small Bite Suture Technique Closure of Midline Laparotomies
Run by Sykehuset Innlandet HF · NCT06858020 · Data updated 2026-11-12
This study is testing if using a special mesh along with a stitching method can help prevent hernias in people who have had surgery on their abdomen.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Sykehuset Innlandet HF Academic / other |
| Locations | 1 site (Hamar) |
| Status | Recruiting |
| Started | February 17, 2025 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | March 5, 2025 |
| Trial ID | NCT06858020 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older scheduled for midline laparotomy who can provide informed consent.
✕Probably not a fit
Patients with a history of abdominal midline hernia mesh repair or those with certain medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter randomized controlled trial evaluates the effectiveness of using a prophylactic polypropylene mesh in addition to the small-bite suture technique for closing midline laparotomy incisions. Conducted across three hospitals in Norway, the study aims to determine whether this combined approach reduces the incidence of incisional hernias compared to the suture technique alone. Participants will be randomly assigned to one of the two closure methods, and the primary outcome will be the occurrence of incisional hernias one year post-surgery. The study seeks to enhance surgical practices in Norway by providing evidence on the use of prophylactic mesh.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of incisional hernias in patients undergoing midline laparotomy, improving their quality of life.
How similar studies have gone: Previous studies have shown success with the use of prophylactic mesh in preventing incisional hernias, but this specific approach has not been widely tested in Norway.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Surgery predominantly done my midline laparotomy * Age 18 years old or older * Written consent by patient/family * Midline laparotomy with delayed closure * No exclusion criteria Exclusion Criteria: * Age under 18 years * Pregnancy * Previous abdominal midline hernia mesh repair * Abdominal compartment syndrome * Linea alba closure not possible * Life expectancy under six months * Hernia in the midline with transverse diameter lager than 2 cm
Where it's running
-
Innlandet Hospital Trust
Hamar, Norway Recruiting
Study contacts
- Study coordinator: Gjertrud H Kjostolfsen, MD
- Email: gjertrud.hole.kjostolfsen@sykehuset-innlandet.no
- Phone: 0047 90236405
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.