Comparing two algorithms for triaging patients with chest pain in the emergency department
PRospective Evaluation of the European Society of Cardiology 0/1-hour Algorithm's Safety and Efficacy for Triage of Patients With Suspected Myocardial Infarction (PRESC1SE-MI)
This study is testing if a new 0/1-hour method for checking heart damage can help doctors better and faster diagnose patients with chest pain compared to the older 0/3-hour method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 64374 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 20 sites (Houston, Texas and 19 other locations) |
| Trial ID | NCT05649384 on ClinicalTrials.gov |
What this trial studies
The PRESC1SE-MI study evaluates the effectiveness of two different algorithms for triaging patients who present with acute chest pain and symptoms of a heart attack in emergency departments. It compares the European Society of Cardiology's 0/3-hour troponin algorithm with the newer 0/1-hour troponin algorithm. The study aims to determine if the 0/1-hour algorithm, which measures cardiac troponin levels at admission and one hour later, provides better outcomes than the traditional 0/3-hour algorithm. This could lead to faster and more accurate diagnoses for patients suspected of having a myocardial infarction.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who present with acute non-traumatic chest pain and have a suspicion of acute myocardial infarction.
Not a fit: Patients with terminal kidney failure requiring dialysis, cardiac arrest, or cardiogenic shock may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to quicker and more accurate diagnosis of heart attacks, improving patient outcomes.
How similar studies have performed: Recent clinical studies suggest that the 0/1-hour algorithm may be superior to the 0/3-hour algorithm, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 and above * Presentation with acute non-traumatic acute chest pain to the emergency department * Suspicion of acute myocardial infarction Exclusion Criteria: * Terminal kidney failure requiring dialysis * Cardiac arrest * Cardiogenic shock
Where this trial is running
Houston, Texas and 19 other locations
- Baylor St. Luke's Medical Center — Houston, Texas, United States (Active_not_recruiting)
- St Andrew's War Memorial Hospital Brisbane — Brisbane, Australia (Active_not_recruiting)
- Vienna General Hospital (AKH Wien) — Wien, Austria (Active_not_recruiting)
- University Central Hospital Helsinki — Helsinki, Finland (Active_not_recruiting)
- Attikon General Hospital Athens — Athens, Greece (Terminated)
- Careggi University Hospital Florence — Florence, Italy (Active_not_recruiting)
- Azienda Ospedaliera San Giovanni Addolorata — Roma, Italy (Active_not_recruiting)
- Hospital Città della Salute e della Scienza di Torino — Torino, Italy (Active_not_recruiting)
- Konkuk University Medical Center — Seoul, Korea, Republic of (Active_not_recruiting)
- Emergency Institute for Cardiovascular Diseases C.C. Iliescu — Bucharest, Romania (Active_not_recruiting)
- Hospital Clinic Barcelona — Barcelona, Spain (Active_not_recruiting)
- University Hospital October 12 Madrid — Madrid, Spain (Active_not_recruiting)
- University Hospital Ramon y Cajal — Madrid, Spain (Active_not_recruiting)
- Hospital Clínico Universitario Valencia — Valencia, Spain (Active_not_recruiting)
- Kantonsspital Aarau — Aarau, Switzerland (Active_not_recruiting)
- St. Claraspital — Basel, Switzerland (Recruiting)
- Kantonsspital Luzern — Luzern, Switzerland (Active_not_recruiting)
- University Hospital Zurich — Zürich, Switzerland (Active_not_recruiting)
- Royal London Hospital — London, United Kingdom (Active_not_recruiting)
- Royal Cornwall Hospitals Treliske — Truro, United Kingdom (Active_not_recruiting)
Study contacts
- Principal investigator: Christian Müller, MD Prof. — University Hospital, Basel, Switzerland
- Study coordinator: Aura Winterhalder
- Email: aura.winterhalder@usb.ch
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.