Comparing treatments for myopia in children
Pharmacological (0.05% Atropine) and Non-pharmacological (Defocused Incorporated Multiple Segments Lens) Treatment Effects on the Children With Different Predicted Myopia Progression Rate Measured by Modified Multifocal Electroretinogram
This study is testing whether a special eye drop or special glasses can help slow down worsening eyesight in children aged 7 to 9 with myopia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 7 Years to 9 Years |
| Sex | All |
| Sponsor | The Hong Kong Polytechnic University Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06282848 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effects of pharmacological treatment with 0.05% atropine and non-pharmacological treatment using DIMS lenses on children with varying predicted rates of myopia progression. Over a 24-month period, 80 participants aged 7 to 9 years will undergo baseline and follow-up eye examinations to assess changes in refractive errors and axial length. The study will also investigate the relationship between retinal activity, measured by multifocal electroretinogram, and myopia progression. Participants will be classified into fast or slow myopia progression groups based on their initial retinal responses.
Who should consider this trial
Good fit: Ideal candidates are children aged 7 to 9 years with a spherical equivalent refractive error between -0.5D and -4D and no history of eye disorders.
Not a fit: Patients with existing eye diseases or systemic conditions such as epilepsy or asthma may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide effective treatment options for controlling myopia progression in children.
How similar studies have performed: Previous studies have shown promising results with atropine and optical interventions for myopia control, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * be aged between 7 and 9 years * have no reported eye disorder and no family history of eye disease * be able to participate in this study for 24 months * not have any current or history of epilepsy * not have any current or history of asthma * have refractive error between 0.50 D and 4.00 D and less than 1.50D of astigmatism with best corrected visual acuity of LogMAR 0.0 or better * have no detected eye diseases or disorders after eye examination, except myopia
Where this trial is running
Hong Kong
- School of Optometry, Hong Kong Polytechnic University — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Henry HL CHAN, PhD — The Hong Kong Polytechnic University
- Study coordinator: Henry HL CHAN, PhD
- Email: henryhl.chan@polyu.edu.hk
- Phone: 85227667937
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.