Comparing treatments for isolated superior mesenteric artery dissection
Official title: Comparison of Conservative and Endovascular Treatment for Spontaneously Isolated Superior Mesenteric Artery Dissection: A Real-world, Multicenter, Observational Study
Run by Xiangya Hospital of Central South University · NCT05342233 · Data updated 2026-11-12
This study is testing whether treating isolated superior mesenteric artery dissection with a watch-and-wait approach or a minimally invasive procedure works better for patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Xiangya Hospital of Central South University Academic / other |
| Locations | 1 site (Changsha, Hunan) |
| Status | Recruiting |
| Started | April 30, 2022 |
| Main results expected | April 1, 2027 |
| Study ends | April 1, 2028 |
| Registry record updated | April 22, 2022 |
| Trial ID | NCT05342233 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with a confirmed diagnosis of isolated superior mesenteric artery dissection and clear symptoms.
✕Probably not a fit
Patients with severe symptoms requiring exploratory laparotomy or those with other significant vascular conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to compare the effectiveness of conservative versus endovascular treatment options for patients diagnosed with spontaneous isolated superior mesenteric artery dissection (SISMAD). It seeks to gather evidence from multiple centers to inform clinical decisions regarding the best therapeutic approach for this increasingly recognized condition. Participants will be monitored to assess treatment outcomes and efficacy based on their individual responses to the interventions. The study will include patients who meet specific eligibility criteria and provide informed consent.
Why it matters
Potential benefit: If successful, this study could help determine the most effective treatment strategy for patients with SISMAD, potentially improving patient outcomes.
How similar studies have gone: While there is limited evidence from prospective multicenter studies on this specific condition, the approach of comparing treatment modalities has shown promise in other vascular conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged 18 and above; 2. Isolated superior mesenteric artery dissection with clear symptoms or history and confirmed by CTA 3. Signed informed consent forms, willing to receive treatments Exclusion Criteria: 1. Symptoms are severe and patients need exploratory laparotomy; 2. Patients with aortic dissection, iliac artery dissection, or autoimmune vasculitis; 3. Patients with mental illness cannot cooperate subjectively; 4. Patients who are allergic to contrast agents, or contraindicated to conservative treatment drugs, and cannot be treated with drugs; 5. Pregnancy and breastfeeding women, or patients who have recent birth plans; 6. Patients who are participating in other clinical projects; 7. Patients are not suitable to participate in this study.
Where it's running
-
Xiangya Hospital of Central South University
Changsha, Hunan, China Recruiting
Study contacts
- Study coordinator: Wang WEI, Ph.D.
- Email: weiwangcsu@csu.edu.cn
- Phone: 13808482650
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.