How anxiety and depression relate to asthma control and the risk of flare-ups
Official title: The Impact of Anxiety/Depression on the Efficacy of Asthma Control Drugs and the Construction of a Predictive Model for the Risk of Acute Asthma Attacks
Run by Xiangya Hospital of Central South University · NCT07679321 · Data updated 2026-11-12
This observational study tests whether anxiety and depression affect how well asthma controller medicines work and whether a risk model can predict asthma flare-ups.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 14 Years and up |
| Sex | All |
| Enrollment | 256 (estimated) |
| Sponsor | Xiangya Hospital of Central South University Academic / other |
| Locations | 1 site (Changsha, Hunan) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | December 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | July 1, 2026 |
| Trial ID | NCT07679321 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults and adolescents aged 14 and older with asthma (newly diagnosed or stable) who are on controller therapy and have complete medical data.
✕Probably not a fit
Patients with significant cognitive impairment, major mental disorders, or current use of antidepressants/anti-anxiety meds may not benefit from the predictive model in its current form.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will collect data from asthma patients receiving controller medications to explore how anxiety and depression relate to asthma control and severity. Participants will undergo baseline assessments, including demographics, medical history, lung function, and psychological scales, with no additional interventions beyond standard care. The researchers aim to build a risk prediction model for acute exacerbations based on anxiety/depression and other factors and to examine associations between mental health and asthma severity.
Why it matters
Potential benefit: If successful, the study could help clinicians identify patients at higher risk for asthma exacerbations and tailor management strategies accordingly.
How similar studies have gone: Previous work in asthma has shown links between mental health and asthma outcomes, supporting the potential value of this observational approach, though predictive modeling in this area remains emerging.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of asthma according to the Global Initiative for Asthma (GINA) 2024 criteria. * Male or female patients aged 14 years or older. * Complete clinical data available. * Newly diagnosed asthma or stable asthma. * Receiving asthma controller medication. Exclusion Criteria: * History of major lung diseases other than asthma, congestive heart failure, cor pulmonale, or recent cardiac or thoracic surgery. * Incomplete medical records. * Cognitive impairment or inability to complete psychological scale assessments. * Clinically diagnosed acute or chronic mental disorders, such as bipolar disorder or schizophrenia. * Current use of antidepressant or anti-anxiety medications. * Pregnancy or lactation.
Where it's running
-
Xiangya Hospital Central South University
Changsha, Hunan, China Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.