Chinese multicenter group studies spontaneous intracerebral hemorrhage in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

CASA is a multicenter, prospective observational registry enrolling about 10,000 adults with imaging-confirmed spontaneous intracerebral hemorrhage and 2,000 healthy controls across 30+ hospitals in China. Researchers collect standardized clinical, imaging, laboratory, lifestyle, and biospecimen data, with follow-ups at 3, 6, and annually up to 10 years. The primary goal is to characterize the distribution of modified Rankin Scale scores at 90 days; secondary goals include 90-day unfavorable outcomes, recurrence, and mortality, among other analyses. The study uses centralized biospecimen processing and stores imaging and clinical data for future research under approved protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria - Intracerebral Hemorrhage Cohort:

* Age 18 years or older.
* Intracerebral hemorrhage confirmed by head computed tomography and/or magnetic resonance imaging.
* Hemorrhage located in a deep cerebral region, cerebral lobe, cerebellum, or brainstem.
* Presentation to a participating hospital within 30 days after symptom onset.
* Written informed consent and broad consent provided in accordance with the ethics-approved process.

Exclusion Criteria - Intracerebral Hemorrhage Cohort:

* Traumatic intracerebral hemorrhage.
* Secondary intracerebral hemorrhage attributed to an arteriovenous malformation, ruptured aneurysm, moyamoya disease, cavernous malformation, hematologic disorder, hemorrhagic tumor, vasculitis, cerebral venous thrombosis, hemorrhagic transformation of cerebral infarction, or other prespecified secondary cause.
* Mixed intracerebral hemorrhage involving multiple deep and lobar locations at onset.
* Severe psychiatric disease that precludes study procedures or follow-up.
* End-stage hepatic or renal failure.
* Autoimmune disease judged by the investigator to materially affect study objectives.
* Active malignant tumor.
* Pregnancy.
* Any other condition that the investigator judges makes participation inappropriate.

Inclusion Criteria - Healthy Control Cohort:

* Age 18 years or older.
* Able to provide written informed consent.
* No known history of intracerebral hemorrhage.

Exclusion Criteria - Healthy Control Cohort:

* Malignant tumor.
* Neurologic disease, particularly any prior intracerebral hemorrhage.
* Any other condition that the investigator judges makes participation inappropriate.

Where it's running

• Xiangya Hospital, Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Le Zhang, Professor, MD
• Email: zlzdzlzd@csu.edu.cn
• Phone: +86 178 7316 7010

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.