Comparing ticagrelor and prasugrel for heart disease treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of ticagrelor and prasugrel as single antiplatelet therapies after patients have undergone dual antiplatelet therapy for coronary artery disease. It will evaluate the pharmacodynamic profiles of both medications to determine if they are comparable in reducing bleeding events without increasing the risk of heart-related complications. The study will involve patients aged 18 to 75 who have been on dual antiplatelet therapy for at least 90 days following a percutaneous coronary intervention. Participants will be randomly assigned to receive either ticagrelor or prasugrel for the duration of the study.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Patients on DAPT with aspirin plus prasugrel 10 mg or ticagrelor 90 mg bid as per standard of care at least 90 days after PCI.
2. Age between 18 and 75 years old
3. Able to provide written informed consent

Exclusion criteria:

1. Prior history of stent thrombosis
2. PCI within 90 days.
3. History of stroke/TIA
4. Age \> 75 years old
5. Weight \< 60 kg
6. History of intracranial hemorrhage
7. On treatment with any oral anticoagulant or chronic low-molecular-weight heparin (at venous thrombosis treatment, not for prophylaxis)
8. Patients with known coagulation disorders
9. Known severe hepatic impairment
10. Hypersensitivity to prasugrel or ticagrelor
11. Pregnant and breastfeeding persons \[persons of childbearing age must use reliable birth control (i.e., oral contraceptives) while participating in the study\]. If the potential subject is a person of childbearing potential, a pregnancy test will be done. If the subject is pregnant, participation in this study will end.

Where it's running

• University of Florida Jacksonville
  Jacksonville, Florida, United States Recruiting

Study contacts

• Principal investigator: Francesco Franchi, MD — University of Florida College of Medicine Jacksonville
• Study coordinator: Francesco Franchi, MD
• Email: francesco.franchi@jax.ufl.edu
• Phone: 9042445515

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.