Comparing Thrombosis Risk in Elderly Patients with Hip Fractures Based on Mobility and Genetics
Is Thromboprotection Preserved in Elderly Ostopenic Patients Who Are Severly Immobilized Before Hip Fracture?
This study is trying to see if older patients with hip fractures and low mobility have a higher risk of blood clots compared to more active seniors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Saglik Bilimleri Universitesi Academic / other |
| Locations | 1 site (İstanbul, Şişli) |
| Trial ID | NCT06959017 on ClinicalTrials.gov |
What this trial studies
This study investigates the levels of the collagen-binding protein Hsp47 in elderly patients with intertrochanteric hip fractures, particularly focusing on those with severe osteopenia. It aims to determine if these patients have a different risk of venous thromboembolism (VTE) compared to more mobile individuals. The researchers will conduct gene expression analysis on patients scheduled for surgery and compare their results with healthy volunteers of the same age group. Additionally, the study will assess complications before and after surgery to provide a comprehensive understanding of the risks involved.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients over 65 years old with intertrochanteric femur fractures and varying levels of mobility.
Not a fit: Patients with a body mass index over 40, severe chronic kidney disease, or a history of recurrent thrombosis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved thromboprophylaxis strategies for elderly patients with hip fractures, potentially reducing the incidence of VTE.
How similar studies have performed: While this approach is novel in its specific focus on genetic analysis related to mobility status in elderly hip fracture patients, similar studies have shown the importance of individualized thromboprophylaxis strategies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>65 years of age * Interthrocanteric femur fracture AO Type 31A1, 31A2, 31A3 * Patients treated proksimal femoral nail * Minor trauma * Fracture mobility score 1,2,3,4,5 * Inial thrombocytes count 150.000-450.000 /µL Exclusion Criteria: * Body mass index \>40 * Fracture mobility score 6 (unknown type) * stage 4 chronic kidney disease * Patients with rheumatological diseases * Patients at serious risk of VTE(Venous thromboembolism) (according to the International Society on Thrombosis and Hemostasis, categorization of venous thromboembolism) : * Active Hematologic Cancer * Antiphospholipid syndrome * History of recurrent thrombosis (DVT) * Paroxysmal nocturnal hemoglobinuria
Where this trial is running
İstanbul, Şişli
- Prof Dr emil Tascıoglu City Hospital — İstanbul, Şişli, Turkey (Recruiting)
Study contacts
- Study coordinator: Berk Gedik, Orthopedic Surgery Resident
- Email: brkgdk@me.com
- Phone: 905065936945
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.