Comparing thermal damage from three electrosurgical conization techniques
Comparison of the Effects of Different Surgical Techniques on the Degree of Thermal Artifact in Patients Undergoing Conization: A Clinical Study
This study will test whether three different electrosurgical conization techniques cause different amounts of thermal damage in women having conization for cervical dysplasia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Saglik Bilimleri Universitesi Academic / other |
| Locations | 1 site (Adana) |
| Trial ID | NCT07372248 on ClinicalTrials.gov |
What this trial studies
The trial compares three modifications of a hybrid conization technique that combines electrosurgery with cold knife excision, using different electrosurgical power settings. Surgical specimens will be examined by pathologists for degree of thermal artifact and quality of margin assessment. Participants are adult women undergoing LLETZ/conization for abnormal cervical cytology or biopsy at a single center in Adana, Turkey. Results will determine which modification produces the least artifact to preserve histologic detail and margin interpretation.
Who should consider this trial
Good fit: Women age 18 or older who have an indication for LLETZ/conization based on abnormal cervical cytology or biopsy and can give written informed consent are eligible, provided they have no prior cervical excisional procedure, are not pregnant, have no active cervical infection, and have no history of cervical cancer.
Not a fit: Patients with prior cervical excision, current pregnancy, active cervical infection, or known cervical cancer would be excluded and would not benefit from participation in this comparison.
Why it matters
Potential benefit: If successful, the preferred technique could reduce heat-related damage to specimens, improving pathology accuracy and potentially lowering the need for repeat procedures.
How similar studies have performed: Electrosurgical conization methods are widely used and known to produce thermal artifacts, but direct head-to-head comparisons of hybrid technique modifications are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:Women aged ≥18 years Indication for LLETZ based on abnormal cervical cytology and/or biopsy Ability to provide written informed consent - Exclusion Criteria: Previous cervical excisional procedure Pregnancy Active cervical infection History of cervical cancer \-
Where this trial is running
Adana
- Adana City Training and Research Hospital — Adana, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Sevda Bas — Universty of Health Science
- Study coordinator: Sevda Bas
- Email: drsevdabas@gmail.com
- Phone: 05300327726
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.