Comparing thermal damage from three electrosurgical conization techniques
Official title: Comparison of the Effects of Different Surgical Techniques on the Degree of Thermal Artifact in Patients Undergoing Conization: A Clinical Study
Run by Saglik Bilimleri Universitesi · NCT07372248 · Data updated 2026-11-12
This study will test whether three different electrosurgical conization techniques cause different amounts of thermal damage in women having conization for cervical dysplasia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Saglik Bilimleri Universitesi Academic / other |
| Locations | 1 site (Adana) |
| Status | Recruiting |
| Started | February 23, 2026 |
| Main results expected | April 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | March 2, 2026 |
| Trial ID | NCT07372248 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women age 18 or older who have an indication for LLETZ/conization based on abnormal cervical cytology or biopsy and can give written informed consent are eligible, provided they have no prior cervical excisional procedure, are not pregnant, have no active cervical infection, and have no history of cervical cancer.
✕Probably not a fit
Patients with prior cervical excision, current pregnancy, active cervical infection, or known cervical cancer would be excluded and would not benefit from participation in this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial compares three modifications of a hybrid conization technique that combines electrosurgery with cold knife excision, using different electrosurgical power settings. Surgical specimens will be examined by pathologists for degree of thermal artifact and quality of margin assessment. Participants are adult women undergoing LLETZ/conization for abnormal cervical cytology or biopsy at a single center in Adana, Turkey. Results will determine which modification produces the least artifact to preserve histologic detail and margin interpretation.
Why it matters
Potential benefit: If successful, the preferred technique could reduce heat-related damage to specimens, improving pathology accuracy and potentially lowering the need for repeat procedures.
How similar studies have gone: Electrosurgical conization methods are widely used and known to produce thermal artifacts, but direct head-to-head comparisons of hybrid technique modifications are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:Women aged ≥18 years Indication for LLETZ based on abnormal cervical cytology and/or biopsy Ability to provide written informed consent - Exclusion Criteria: Previous cervical excisional procedure Pregnancy Active cervical infection History of cervical cancer \-
Where it's running
-
Adana City Training and Research Hospital
Adana, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Sevda Bas — Universty of Health Science
- Study coordinator: Sevda Bas
- Email: drsevdabas@gmail.com
- Phone: 05300327726
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.