Comparing the effectiveness of different types of prosthetic knees for amputees

Comparing the Effectiveness and Cost-effectiveness of Conventional Mechanical Knees and Microprocessor-controlled Knees: a Prospective Cohort Study

Observational University Medical Center Groningen · NCT06031922

This study is testing if microprocessor-controlled knees help amputees walk better and feel more active compared to regular prosthetic knees.

Quick facts

Study typeObservational
Enrollment28 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity Medical Center Groningen Academic / other
Locations9 sites (Breda and 8 other locations)
Trial IDNCT06031922 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate the effectiveness of microprocessor-controlled knees (MPKs) compared to non-microprocessor-controlled knees (NMPKs) in individuals with lower limb amputations in the Netherlands. Participants will undergo a series of physical tests, complete questionnaires, and wear an activity tracker over a year to assess their walking distance and overall functional performance. The study will involve a baseline measurement, a six-week trial with the MPK, and follow-up assessments to compare outcomes. The research considers various levels of the International Classification of Functioning (ICF) model to provide a comprehensive understanding of the impact of prosthetic knee types on users.

Who should consider this trial

Good fit: Ideal candidates include individuals with unilateral transfemoral amputation or knee-disarticulation who are at least one year post-amputation and eligible for a trial on an MPK.

Not a fit: Patients with bilateral amputations, those who have undergone osseointegration, or individuals with prior experience using an MPK may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prosthetic options and rehabilitation strategies for amputees, enhancing their mobility and quality of life.

How similar studies have performed: Other studies have shown promising results in comparing different prosthetic knee technologies, indicating that this approach is supported by existing literature.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* At least one year post amputation
* Unilateral transfemoral amputation or knee-disarticulation
* Eligible for a trial on an MPK
* Able to read and write in Dutch
* Use a prosthesis with a socket

Exclusion Criteria:

* Bilateral amputation
* Osseointegration
* Previous experience with an MPK

Where this trial is running

Breda and 8 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions AmputationProsthesis UserProsthesisEffectivenesstransfemoral amputationknee-disarticulationMicroprocessor controlled kneeprosthetic knee
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.