Comparing surgical methods for retinal detachment repair
Official title: Rhegmatogenous rEtinal Detachment With or withOut Scleral Buckle (REDOS) Trial: a Factorial, Randomized Controlled Trial
Run by CHU de Quebec-Universite Laval · NCT05863312 · Data updated 2026-11-12
This study is testing two different surgical methods for fixing retinal detachment to see which one works better for patients and how different types of gas used during surgery affect their recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 560 (estimated) |
| Sponsor | CHU de Quebec-Universite Laval Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Status | Recruiting |
| Started | September 26, 2023 |
| Main results expected | July 2027 |
| Study ends | July 2028 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT05863312 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older diagnosed with rhegmatogenous retinal detachment.
✕Probably not a fit
Patients with complex retinal conditions such as proliferative vitreoretinopathy or chronic retinal detachment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to analyze and compare the surgical outcomes of two methods for repairing primary rhegmatogenous retinal detachment (RRD): pars plana vitrectomy (PPV) alone and PPV combined with scleral buckle (PPV-SB). Additionally, it will evaluate the effectiveness of two types of gas tamponade, sulfur hexafluoride (SF6) and perfluoropropane (C3F8). Approximately 560 eligible patients will be randomized to receive one of the surgical interventions and will be followed for one year post-surgery to assess anatomical success, visual outcomes, complications, and quality of life. The study seeks to provide robust evidence to guide surgical decisions in RRD repair.
Why it matters
Potential benefit: If successful, this study could improve surgical outcomes and quality of life for patients with retinal detachment.
How similar studies have gone: Previous studies have shown varying success with different surgical approaches for retinal detachment, but this specific factorial design is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Diagnosis of rhegmatogenous retinal detachment Exclusion Criteria, retinal detachment with: * Proliferative vitreoretinopathy (PVR) grade ≥C2 * Chronic RRD with duration \>3 months * Proliferative diabetic retinopathy with tractional retinal detachment (RD) * Macular holes * Epiretinal membrane grade 3 or 4 * Traumatic RD * Giant retinal tears * Retinal dialysis * Foveoschisis * Wet age-related macular degeneration * Endophthalmitis * Acute retinal necrosis * Coats disease * Retinopathy of prematurity * Retinoschisis * Retinal colobomas * Prior glaucoma surgery or strabismus surgery (favoring PPV only) * Superior RD extent less than 3 clock hours (favoring PPV only)
Where it's running
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Hôpital du Saint-Sacrement, CHU de Québec - Université Laval
Québec, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Ali Dirani, MD MSc MPH — CHU de Québec - Université Laval
- Study coordinator: Julie Mauger, BSc
- Email: cuo.recherche@fmed.ulaval.ca
- Phone: 418-682-7511
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Biometry in Eyes with Silicon Oil After PPV
This study tests optical and ultrasound biometry in people with retinal detachment who are getting pars plana vitrectomy with silicone oil, to see how measurements compare before surgery and about a month after.
-
Finding protein biomarkers for AMD, diabetic retinopathy, and retinal detachment
This project will test whether proteins found in blood and eye fluids can help diagnose or predict outcomes for adults with AMD, diabetic retinopathy, or retinal detachment.
-
Spring-loaded syringe versus vitrectomy machine program for removing silicone oil after retinal detachment surgery
This test compares a modified spring-loaded syringe with a vitrectomy-machine silicone oil extraction program to see which is faster and safer for people having silicone oil removed after pars plana vitrectomy.
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Comparing surgery times for UNITY® VCS and CONSTELLATION® Vision System
This study will see if the UNITY® VCS or the CONSTELLATION® Vision System leads to shorter combined cataract and vitrectomy (phacovitrectomy) surgery times for adults planned for 25‑gauge procedures.
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Oral nicotinamide riboside to protect the macula after retinal detachment
This will test whether taking oral nicotinamide riboside around the time of surgery helps preserve central vision in adults with a macula-off retinal detachment.
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Using Ursodeoxycholic Acid to Improve Recovery After Retinal Detachment Surgery
This study is testing if a medication called Ursodeoxycholic Acid can help people recover their vision better after surgery for a specific type of retinal detachment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.