Comparing Remimazolam and Midazolam for Sedation in Critically Ill Patients on Ventilators

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of remimazolam versus midazolam on the duration of mechanical ventilation in critically ill patients. It is a multicenter, single-blind, randomized controlled trial where patients will be assigned to receive either remimazolam or midazolam for sedation. The primary goal is to determine if remimazolam can reduce the time patients spend on mechanical ventilation compared to midazolam. Patients aged 18 to 80 who are mechanically ventilated within 48 hours of ICU admission and expected to stay in the ICU for over 72 hours will be enrolled.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Critical ill patients that are mechanically ventilated within the first 48h of admission to the ICU and who would remain in the ICU for over 72h were enrolled in this study.
2. Age 18-80 years.
3. Voluntary informed consent.

Exclusion Criteria:

1. Surgical treatment is performed within 24 hours.
2. Craniocerebral injury, post neurosurgery, non drug coma, mental illness or peripheral neuropathy.
3. Heart rates are less than 50 beats / min or severe atrioventricular block without pacemaker support.
4. The mean arterial pressure is less than 55 mmHg even though fluids and vasoactive drugs are administrated.
5. Patients who are known or suspected allergy to benzodiazepines, propofol, dexmedetomidine or opioids.
6. History of alcohol and drug abuse.
7. End stages of lung diseases, such as pulmonary fibrosis, lung damage, etc.
8. Pregnancy.

Where it's running

• Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Zhanguo Liu, M.D.PhD — Department of Critical Care Medicine of Zhujiang Hospital
• Study coordinator: Jing Cai
• Email: caijing78@hotmail.com
• Phone: +86-2062782927

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.