Comparing Ray‑Tracing Guided LASIK with three other laser vision correction methods for myopia and astigmatism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized contralateral‑eye comparison where each subject receives Ray‑Tracing Guided LASIK in one eye and a comparator procedure in the other eye. The trial is conducted in three phases, each enrolling at least 44 subjects to compare Ray‑Tracing LASIK with KLEx (Zeiss VisuMax), Wavefront‑Optimized LASIK (Alcon EX500), and Topography‑Guided LASIK (Contoura on Alcon EX500) respectively. Randomization determines which eye receives Ray‑Tracing LASIK, and subjects follow a standard postoperative schedule with visits at 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months. Participants are recruited from Hoopes Vision patients and treated at the Hoopes Moshirfar Research Center in Draper, Utah.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 22-50 at the time of consent
2. Diagnosis of myopia or myopia with astigmatism with Preoperative manifest spherical equivalent refraction of ≥ -2.00 and ≤ -9.00 D (-2.00 D through -9.00 D)
3. Preop Spherical component of ≥ -2.00 and ≤ -8.00 D (-2.00 D through -8.00 D)
4. Refractive Cylinder of ≤ -3.00 D (0.00 through -3.00 D)
5. BCVA of 20/20 or better in each eye (83 or more letters on the ETDRS Chart)
6. Subjects must have a stable refraction which is defined as a change in spherical equivalent no greater than 0.50 D comparing the screening visit manifest refraction to a previous refraction, spectacle Rx, or contact lens Rx, 12 months or older.
7. Subjects who are contact lens wearers must discontinue the use of soft lenses (spherical or toric) for at least 5 days and hard or gas-permeable lenses for at least 4 weeks prior to the preoperative screening evaluation. Hard or gas-permeable lens wearers must not return to contact lens use before surgery. Soft lens wearers may resume contact lens wear after all preoperative testing is completed, but must discontinue lens use at least 5 days before surgery.
8. Acceptable preoperative tomography and examination results for refractive procedures as determined by the Principal Investigator.
9. Surgical plan includes treatment target for emmetropia in both eyes, and no monovision.
10. Subject is capable and willing to use postoperative medications as prescribed.
11. Subject has ability to successfully complete all preoperative and postoperative questionnaires, testing, and exam visits.
12. Subject is willing and able to return for all postoperative examinations.

Exclusion Criteria:

1. Clinically significant dry eye on clinical examination, as determined by the investigator
2. Irregular astigmatism, keratoconus, keratoconus suspect, or abnormal corneal tomography
3. History of corneal dystrophies or guttata
4. History of herpetic keratitis or active disease
5. History of prior refractive surgery
6. History of glaucoma or glaucoma suspect
7. History of uncontrolled diabetes, unstable hypertension, or unstable autoimmune disease.
8. Females who are pregnant, breastfeeding, or intend to become pregnant any time during the study as determined by verbal inquiry.
9. The Principal Investigator has determined the subject not to be a good candidate for the study.

Where it's running

• Hoopes Moshirfar Research Center
  Draper, Utah, United States Recruiting

Study contacts

• Principal investigator: Majid Moshirfar, MD — Hoopes Vision
• Study coordinator: Steven H Linn, OD
• Email: slinn@hoopesvision.com
• Phone: 801-988-7342

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating a device for screening vision problems in young children

  This study is testing a new device to see if it can effectively find vision problems in children aged 3 to 8, whether they wear glasses or not.

  Recruiting Essilor International · Nancy, France and 1 other locations · NCT06882408

• Two monthly silicone hydrogel multifocal toric contact lenses in wearers with astigmatism and myopia

  This study tests whether two popular soft multifocal toric contact lenses perform differently in adults who need vision correction for astigmatism and myopia.

  Recruiting CooperVision International Limited (CVIL) · New York, New York and 2 other locations · NCT07829419

• Seeing clearly in low light after Ray-Tracing guided LASIK

  A trial tests how well WaveLight Plus LASIK works for people with myopia and astigmatism and whether patients are satisfied after the procedure.

  Recruiting Phase 4 Vance Thompson Vision · Sioux Falls, South Dakota · NCT07790185

• Orthokeratology contact lenses with a 5 mm optic zone diameter

  This study tests Paragon CRT lenses with a 5 mm optic zone in kids and young adults to see how well they fit, how well they vision, and how comfortable they are at night.

  Recruiting at 2 sites CooperVision International Limited (CVIL) · Pleasanton, California and 2 other locations · NCT07751172

• SMILE in one eye vs Ray tracing-guided LASIK in the fellow eye

  This study tests two laser vision correction methods—SMILE in one eye and ray-tracing guided LASIK in the other eye—to see which provides better vision and quality of life for adults with myopia and astigmatism.

  Recruiting Phase 4 Stanford University · Palo Alto, California · NCT07721714

• WaveLight Plus LASIK for nearsightedness and astigmatism

  This study will try WaveLight Plus LASIK in adults with nearsightedness and astigmatism to see if it improves vision, satisfaction, and quality of life over three months.

  Recruiting Laser Defined Vision · Greensboro, North Carolina · NCT07127757

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.