Comparing protein levels in saliva and gum fluid of healthy individuals and those with periodontitis
Official title: Comparison of Salivary and Crevicular Protein Concentrations of FIBA, PLMN, HEMO and ApoH in Healthy and Periodontitis Patients
Run by University Hospital, Montpellier · NCT05511454 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing the protein levels in saliva and gum fluid from healthy people and those with gum disease to see if it can help us understand how the disease works and its links to overall health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 118 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT05511454 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals seeking dental care who are either healthy or diagnosed with periodontitis according to the Chicago 2018 classification.
✕Probably not a fit
Patients who have undergone previous periodontal treatment or are currently pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the concentrations of specific proteins in saliva and crevicular fluid between healthy individuals and patients diagnosed with periodontitis. By analyzing these protein levels, the researchers hope to identify potential biomarkers that could help in understanding the disease's progression and its relationship with systemic health issues. The study will involve collecting samples from participants who meet specific inclusion criteria based on their periodontal health status. The findings could provide insights into the underlying mechanisms of periodontitis and its associated risk factors.
Why it matters
Potential benefit: If successful, this study could lead to the identification of biomarkers that improve the diagnosis and management of periodontitis.
How similar studies have gone: While some studies have explored biomarkers in periodontitis, this specific comparison of salivary and crevicular protein concentrations is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Control Group: * Patients consulting the Center for Dental Care, Education and Research for the care of their periodontal pathology. * Patients with periodontal health according to the 2018 Chicago Classification. Case Group: * Patients consulting the Center for Dental Care, Education and Research for the care of their periodontal pathology. * Patients with periodontitis according to the Chicago 2018 classification criteria. Exclusion Criteria: General: * Pregnancy in progress or planned during the study period, Pregnant or breastfeeding women. * Adult protected by law or patient under tutorship or curatorship. * Participation in other ongoing biomedical research. * Failure to obtain written informed consent after a reflection period. * Not be affiliated to a French social security system or a beneficiary of such a system. Case Group: * Patients with previous periodontal treatment or maintenance. Control Group: * There is no prohibition against subjects participating in other research simultaneously.
Where it's running
-
Centre de Soins Dentaires
Montpellier, France Recruiting
Study contacts
- Study coordinator: Margaux Dr VIGNON
- Email: m-vignon@chu-montpellier.fr
- Phone: 06.52.82.07.82
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.