Comparing methods to measure lung stress in ventilated patients
Comparison of Different Methods to Calculate Pendelluft by Electrical Impedance Tomography in Patients Undergoing Invasive Mechanical Ventilation Under Pressure Support Mode
NA · University of Sao Paulo General Hospital · NCT06494215
This study is testing different ways to measure lung stress in patients on ventilators to see which method helps keep their lungs healthier.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Sao Paulo General Hospital (other) |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT06494215 on ClinicalTrials.gov |
What this trial studies
This study investigates different methods for calculating Pendelluft, a phenomenon that can cause lung damage in mechanically ventilated patients. Using electrical impedance tomography, the research will monitor respiratory mechanics and regional ventilation while assessing the stress on lung parenchyma. Patients will undergo a series of measurements involving pressure support variations and arterial blood-gas analysis to evaluate the impact of Pendelluft on lung health. The goal is to determine the most effective method for estimating local driving pressure and regional volume during mechanical ventilation.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are undergoing invasive mechanical ventilation due to respiratory failure.
Not a fit: Patients who are sedated, under neuromuscular blockade, or have contraindications for the required procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilator management strategies that minimize lung injury in critically ill patients.
How similar studies have performed: While the approach of using electrical impedance tomography is gaining interest, this specific comparative analysis of Pendelluft measurement methods is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients under invasive mechanical ventilation intubated due to respiratory failure in pressure support mode (weaning phase) Exclusion Criteria: * Age less than 18 years; sedation or neuromuscular blockade; absence of respiratory effort; contraindications to esophageal balloon cathether positioning or electrical impedance tomography belt positioning; presence of pneumothorax or active air leaks; hemodynamic instability; absence of informed consent.
Where this trial is running
São Paulo
- Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP — São Paulo, Brazil (RECRUITING)
Study contacts
- Principal investigator: Marcelo BP Amato — University of Sao Paulo General Hospital
- Study coordinator: Marcelo BP Amato, MD PhD
- Email: marcelo.amato@hc.fm.usp.br
- Phone: 3061-7361
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Asynchrony, Patient-Ventilator, ARDS, Respiratory Insufficiency, Respiratory Effort-Related Arousal |, Patient |, Respiratory Measures and Ventilator Management, Pendelluft, Ventilator-patient asynchrony