Comparing lidocaine and opioids for anesthesia in emergency surgery
Comparison of Hemodynamic Effect of Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy: a Randomized Controlled Trial.
This study tests whether using lidocaine instead of opioids for anesthesia during emergency surgery can help keep patients' blood pressure stable and improve their recovery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06772727 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of lidocaine-based anesthesia compared to traditional opioid-based anesthesia in patients undergoing emergency laparotomy. The focus is on minimizing post-induction hypotension, a common complication associated with this type of surgery. The study involves adult patients classified as ASA class I-III and aims to maintain stable vital signs and adequate tissue perfusion during the procedure. Various anesthetic agents, including lidocaine, fentanyl, and propofol, will be administered to assess their impact on patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are adult patients of both genders classified as ASA class I-III who require emergency laparotomy.
Not a fit: Patients with severe cardiac morbidities, uncontrolled hypertension, or those on vasopressor infusion may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to safer anesthesia protocols and improved outcomes for patients undergoing emergency laparotomy.
How similar studies have performed: Previous studies have shown promising results with lidocaine in various surgical settings, suggesting potential benefits in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult patients 2. Both gender 3. American Society of Anesthesiologists (ASA) class I-III undergoing emergency laparotomy. Exclusion Criteria: 1. Patient refusal 2. Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) 3. Baseline mean arterial pressure \<75 mmHg 4. Patients on vasopressor infusion, 5. Patients with high shock index (heart rate / systolic blood pressure \>1) 6. Pregnant or lactating women, 7. Allergy of any of the study drugs 8. Hypertensive patients and patients on beta blockers. 9. Uncontrolled hypertensive patients or patients receiving angiotensin converting enzyme (ACE) inhibitors preoperatively. 10. Opioid drug abusers. 11. Patients with increased intracranial tension.
Where this trial is running
Cairo
- Faculty of Medicine, Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Samar M Abdel Azeim Ghazala, M.Sc. — Cairo University
- Study coordinator: Kareem MA Nawwar, M.D.
- Email: drknawwar@cu.edu.eg
- Phone: +201003878369
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.