Comparing lidocaine and dexmedetomidine for reducing bleeding during sinus surgery
A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Patients Undergoing Functional Endoscopic Sinus Surgery
This study is testing whether using lidocaine or dexmedetomidine can help reduce bleeding during sinus surgery for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06848764 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effects of lidocaine and dexmedetomidine infusions on intraoperative bleeding in patients undergoing functional endoscopic sinus surgery (FESS). FESS is a common procedure in ENT that can be complicated by excessive bleeding, which impairs visibility during surgery. The study will evaluate the safety and efficacy of these two medications to improve surgical conditions. Participants will be monitored for bleeding control and overall surgical outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 who are scheduled for elective functional endoscopic sinus surgery and are classified as ASA physical status I or II.
Not a fit: Patients with diabetes, coagulation disorders, or significant cardiovascular or respiratory issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical outcomes and reduced complications during sinus surgeries.
How similar studies have performed: While similar approaches have been explored, this specific comparison of lidocaine and dexmedetomidine in the context of FESS is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years old. * American Society of Anesthesiologists (ASA) physical status I - II. * Scheduled for elective functional endoscopic sinus surgery. Exclusion Criteria: * Diabetes mellitus. * Coagulation disorders. * Kidney and liver dysfunction. * Cerebrovascular disease. * Cardiovascular problems. * High blood pressure. * Asthma. * Chronic obstructive pulmonary disease (COPD). * End organ damage. * Psychosis. * Taking antipsychotic drugs. * Allergy to study drugs. * Substance abuse. * Taking beta blockers. * Heart rate of \< 55 beat/minute.
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Ahmed M Eldemerdash, MD
- Email: ahmedmonier@med.asu.edu.eg
- Phone: 00201114959206
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.