Comparing lidocaine and dexmedetomidine for pain management in thoracic surgery
A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
This study is testing whether using lidocaine, dexmedetomidine, or both together can help people having thoracic surgery feel less pain after their operation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06837519 on ClinicalTrials.gov |
What this trial studies
This study compares the effects of lidocaine and dexmedetomidine infusions, both individually and in combination, on managing perioperative pain in patients undergoing video-assisted thoracoscopic surgery (VATS). The research focuses on improving postoperative pain control, which is essential for reducing complications and enhancing recovery. By evaluating pain intensity, opioid consumption, and recovery parameters, the study aims to identify the most effective pain management strategy for VATS patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are undergoing video-assisted thoracoscopic surgery and have an ASA physical status of I or II.
Not a fit: Patients with hypersensitivity to the study drugs, significant comorbidities, or those requiring chronic pain management may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies, enhancing recovery and patient satisfaction after thoracic surgery.
How similar studies have performed: Previous studies have shown positive outcomes with both lidocaine and dexmedetomidine in pain management, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years old. * Both sexes. * American Society of Anesthesiologists (ASA) physical status of I, II. * Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia. Exclusion Criteria: * Hypersensitivity to any of the used drugs. * Coagulation disorder. * Body mass index \>35 kg/m2. * History of chronic pain requiring daily opioids/steroids/clonidine/other α2 agonist/analgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug/alcohol abuse. * Contraindication to the use of local anesthetics. * Cardiovascular disease. * Severe respiratory, renal or hepatic impairment. * Insulin-dependent diabetes mellitus. * Central nervous system or psychiatric disease.
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Sarah A Afifi, MD
- Email: Sarah606060@gmail.com
- Phone: 0501035864
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.