Comparing Labetalol and Nifedipine for Managing Postpartum Hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of Labetalol and Nifedipine in managing postpartum hypertension and reducing the risk of hospital readmission and hypertensive complications. Patients who meet the inclusion criteria will be randomly assigned to receive either Labetalol or Nifedipine, with treatment escalation determined by their primary provider. The study will enroll a total of 600 patients, with 300 in each treatment arm, and monitor them for signs of hypotension and medication side effects. The goal is to achieve normotension for at least 12 hours before discharge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Any patient admitted for delivery by cesarean or vaginal delivery at 24 weeks gestation or greater with hypertension(HTN). Hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN. Following enrollment, treatment will be escalated at discretion of primary provider with the goal of normotension.

Exclusion Criteria:

History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema

* Contraindication to either Nifedipine or Labetalol
* HR \<60 or \>110
* Native language other than English or Spanish

Where it's running

• Nebraska Methodist Women's Hospital
  Omaha, Nebraska, United States Recruiting

Study contacts

• Principal investigator: Todd Lovgren, MD — Nebraska Methodist Health System
• Study coordinator: Todd Lovgren, MD
• Email: todd.lovgren@nmhs.org
• Phone: 4028151970

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.