Comparing isolated ultrafiltration to conventional hemodialysis in kidney disease patients
Official title: Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
Run by Medical University of Graz · NCT05642156 · Data updated 2026-11-12
This study is testing if a new method called isolated ultrafiltration can help people with end-stage kidney disease have a better experience during dialysis compared to the usual method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 32 (estimated) |
| Sponsor | Medical University of Graz Academic / other |
| Locations | 1 site (Graz) |
| Status | Recruiting |
| Started | November 2, 2022 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT05642156 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with end-stage kidney disease who are stable at their dry weight and experience significant interdialytic weight gain.
✕Probably not a fit
Patients with implanted medical devices, those treated with hemodiafiltration, or individuals with severe hyperkalemia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of isolated ultrafiltration (iso-UF) on hemodynamic stability in patients with end-stage kidney disease undergoing hemodialysis. It aims to assess changes in peripheral resistance, osmolality, cardiac output, and cardiac power index, while exploring correlations with intradialytic hypotension (IDH) episodes. The study seeks to determine whether iso-UF can improve dialysis quality by reducing the time spent on dialysis compared to conventional methods. The research is motivated by the need for updated evidence on iso-UF's benefits, as previous studies may not reflect current techniques.
Why it matters
Potential benefit: If successful, this approach could lead to improved cardiovascular outcomes and reduced complications for patients undergoing hemodialysis.
How similar studies have gone: Previous studies on isolated ultrafiltration have shown limited success, indicating a need for further investigation into its efficacy with modern techniques.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written consent of the participant after being informed * At least 18 years of age * End stage kidney disease patient undergoing hemodialysis * Dry weight stable for a minimum of one month * Interdialytic weight gain of \>2 liters in the short interdialytic interval Exclusion Criteria: * No informed consent was obtained * Patients with a pacemaker or implanted medical device that prevents compliance with study regulations * Patients treated with hemodiafiltration * Patients treated with medium cut-off membranes (Theranova, Baxter) * Patients with recurrent severe hyperkalemia after the short interdialytic interval (K+ concentration \> 6.0 mmol/L, requiring more than 2 hours of dialysis to ameliorate the post-dialytic shift from other compartments. * Women of childbearing age not using contraception
Where it's running
-
Medical University of Graz
Graz, Austria Recruiting
Study contacts
- Study coordinator: Alexander H Kirsch
- Email: alexander.kirsch@medunigraz.at
- Phone: +43316385
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.