Comparing hot and cold methods for removing colorectal polyps
Official title: A Comparison of the Resection Rate for Hot and Cold Snare Polypectomy of Colorectal Polyps (10-15 Mm) - a Randomized Controlled Trial (COLDSNAP-2)
Run by Technical University of Munich · NCT04816292 · Data updated 2026-11-12
This study is testing whether using hot or cold methods to remove certain types of polyps during a colonoscopy is safer and more effective for patients who need this procedure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 850 (estimated) |
| Sponsor | Technical University of Munich Academic / other |
| Locations | 1 site (München, Bavaria) |
| Status | Recruiting |
| Started | November 5, 2024 |
| Main results expected | January 1, 2026 |
| Study ends | March 2026 |
| Registry record updated | November 12, 2024 |
| Trial ID | NCT04816292 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals scheduled for colonoscopy with at least one adenomatous polyp measuring 10-15 mm.
✕Probably not a fit
Patients with severe comorbidities, inflammatory bowel disease, or those requiring emergency colonoscopy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness and safety of hot snare polypectomy (HSP) and cold snare polypectomy (CSP) in removing adenomatous polyps sized 10-15 mm during colonoscopy. HSP uses electrocautery, which can lead to adverse events, while CSP is gaining popularity for its ease and reduced complications. The study will enroll patients who require colonoscopy and have at least one adenomatous polyp within the specified size range. Participants will be randomly assigned to receive either HSP or CSP, and outcomes will be measured to determine the resection rates and safety profiles of both techniques.
Why it matters
Potential benefit: If successful, this study could lead to safer and more effective methods for polyp removal, potentially reducing the risk of colorectal cancer.
How similar studies have gone: Previous studies have shown promising results for cold snare polypectomy, indicating its potential advantages over traditional methods, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Indication for colonoscopy * at least 1 adenomatous polyp 10-15 mm * provided written informed consent Exclusion Criteria: * American Society of Anaesthesiologists class IV or higher * florid inflammatory bowel disease * emergency indication for colonoscopy * haemorrhagic diathesis * continued dual antiplatelet therapy * continued anticoagulant therapy
Where it's running
-
Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technische Universität München
München, Bavaria, Germany Recruiting
Study contacts
- Study coordinator: Veit Phillip, MD
- Email: veit.phillip@mri.tum.de
- Phone: +49894140
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.