Comparing high-flow oxygen therapy and non-invasive ventilation for respiratory failure
Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway in Hypoxemic Critical Care Patients: a Physiological Randomized Controlled Trial
This study is testing whether high-flow oxygen therapy or non-invasive ventilation helps critically ill adults with breathing problems improve their lung function better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier, Languedoc-Roussillon) |
| Trial ID | NCT05643911 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effects of high-flow nasal cannula oxygen therapy (HFNC) versus non-invasive ventilation (NIV) on lung volumes in patients experiencing hypoxemic respiratory failure in the Intensive Care Unit (ICU). Using CT scans, the research will assess whether NIV leads to a greater increase in lung volumes compared to HFNC. The study targets critically ill adults who require oxygen therapy to maintain adequate oxygen saturation levels. By comparing these two treatment methods, the study seeks to provide insights into the most effective approach for managing respiratory failure.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are experiencing hypoxemia and require oxygen therapy in the ICU.
Not a fit: Patients who are contraindicated for non-invasive ventilation or those requiring immediate intubation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment strategies for patients with respiratory failure, potentially reducing ICU mortality rates.
How similar studies have performed: Previous studies have explored similar interventions, but this specific comparison of HFNC and NIV in critically ill patients is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with hypoxemia at any time of ICU stay defined as follow: standard oxygen therapy flow ≥ 3L/min to maintain a pulsed oxygen saturation ≥ 95% * Adult (age ≥ 18 years) * (2) A CT scan prescribed by the physician in charge of the patient as part of the exploration of the patient's pathology and not as part of a "dedicated" prescription for the study. Exclusion Criteria: * NIV contraindication (need for immediate endotracheal intubation and mechanical ventilation; hemodynamic instability defined by systolic blood pressure \< 90 mmHg or mean blood pressure \< 65 mmHg, use of vasopressors; Glasgow Coma Scale score of 12 points or less) * History of recent facial trauma not compatible with the use of nasal cannulas * Pregnancy * Refusal of study participation * protected person * Patient not affiliated to the social security system or not benefiting from such a system * Lack of signed informed consent
Where this trial is running
Montpellier, Languedoc-Roussillon
- Centre Hospitalier Universitaire Montpellier, Saint Eloi — Montpellier, Languedoc-Roussillon, France (Recruiting)
Study contacts
- Study coordinator: Samir JABER
- Email: s-jaber@chu-montpellier.fr
- Phone: 0033467337271
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.