Clinical trial Recruiting at 1 site Observational

Comparing heart function recovery in Takotsubo syndrome and heart attacks

Official title: STAMI- Stunning in Takotsubo Versus Acute Myocardial Infarction

Run by Vastra Gotaland Region · NCT04448639 · Data updated 2026-11-12

This study is trying to see how heart function recovers in people with Takotsubo syndrome compared to those who have had a heart attack, to understand why TS patients often do better.

Quick facts

Study typeObservational
SexAll
Enrollment125 (estimated)
SponsorVastra Gotaland Region
Government
Locations1 site (Gothenburg)
StatusRecruiting
StartedDecember 12, 2019
Main results expectedJanuary 2024
Study endsDecember 2030
Registry record updatedDecember 12, 2023
Trial IDNCT04448639 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals diagnosed with either STEMI or Takotsubo syndrome who are scheduled for coronary angiography within 12 hours of symptom onset.

Probably not a fit

Patients experiencing cardiogenic shock or those unable to comply with the study protocol may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The STAMI study aims to investigate the differences in myocardial stunning between patients with Takotsubo syndrome (TS) and those with ST-elevation myocardial infarction (STEMI). This observational study will enroll 100 STEMI patients and 25 TS patients, assessing their heart function recovery through echocardiography, laboratory tests, and ECG at various time points after angiography. By comparing the temporal patterns of recovery, the study seeks to understand why TS patients often have better prognoses despite more pronounced myocardial stunning. The findings could provide insights into treatment strategies for acute heart failure.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for patients experiencing acute myocardial stunning.

How similar studies have gone: While there have been studies on myocardial stunning, this head-to-head comparison of TS and STEMI is novel and has not been previously conducted.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* STEMI or TS with planned coronary angiography within 12 hours from the onset of symptoms
* Written consent

Exclusion Criteria:

* Cardiogenic shock, defined as Killip class IV
* Expected inability to comply with the protocol

Where it's running

  • Department of Cardiology; Sahlgrenska University Hospital
    Gothenburg, Sweden
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.