Comparing heart function recovery in Takotsubo syndrome and heart attacks
Official title: STAMI- Stunning in Takotsubo Versus Acute Myocardial Infarction
Run by Vastra Gotaland Region · NCT04448639 · Data updated 2026-11-12
This study is trying to see how heart function recovers in people with Takotsubo syndrome compared to those who have had a heart attack, to understand why TS patients often do better.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 125 (estimated) |
| Sponsor | Vastra Gotaland Region Government |
| Locations | 1 site (Gothenburg) |
| Status | Recruiting |
| Started | December 12, 2019 |
| Main results expected | January 2024 |
| Study ends | December 2030 |
| Registry record updated | December 12, 2023 |
| Trial ID | NCT04448639 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with either STEMI or Takotsubo syndrome who are scheduled for coronary angiography within 12 hours of symptom onset.
✕Probably not a fit
Patients experiencing cardiogenic shock or those unable to comply with the study protocol may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The STAMI study aims to investigate the differences in myocardial stunning between patients with Takotsubo syndrome (TS) and those with ST-elevation myocardial infarction (STEMI). This observational study will enroll 100 STEMI patients and 25 TS patients, assessing their heart function recovery through echocardiography, laboratory tests, and ECG at various time points after angiography. By comparing the temporal patterns of recovery, the study seeks to understand why TS patients often have better prognoses despite more pronounced myocardial stunning. The findings could provide insights into treatment strategies for acute heart failure.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients experiencing acute myocardial stunning.
How similar studies have gone: While there have been studies on myocardial stunning, this head-to-head comparison of TS and STEMI is novel and has not been previously conducted.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * STEMI or TS with planned coronary angiography within 12 hours from the onset of symptoms * Written consent Exclusion Criteria: * Cardiogenic shock, defined as Killip class IV * Expected inability to comply with the protocol
Where it's running
-
Department of Cardiology; Sahlgrenska University Hospital
Gothenburg, Sweden Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.