Comparing heart function recovery in Takotsubo syndrome and heart attacks
STAMI- Stunning in Takotsubo Versus Acute Myocardial Infarction
This study is trying to see how heart function recovers in people with Takotsubo syndrome compared to those who have had a heart attack, to understand why TS patients often do better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 125 (estimated) |
| Sex | All |
| Sponsor | Vastra Gotaland Region Government |
| Locations | 1 site (Gothenburg) |
| Trial ID | NCT04448639 on ClinicalTrials.gov |
What this trial studies
The STAMI study aims to investigate the differences in myocardial stunning between patients with Takotsubo syndrome (TS) and those with ST-elevation myocardial infarction (STEMI). This observational study will enroll 100 STEMI patients and 25 TS patients, assessing their heart function recovery through echocardiography, laboratory tests, and ECG at various time points after angiography. By comparing the temporal patterns of recovery, the study seeks to understand why TS patients often have better prognoses despite more pronounced myocardial stunning. The findings could provide insights into treatment strategies for acute heart failure.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with either STEMI or Takotsubo syndrome who are scheduled for coronary angiography within 12 hours of symptom onset.
Not a fit: Patients experiencing cardiogenic shock or those unable to comply with the study protocol may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients experiencing acute myocardial stunning.
How similar studies have performed: While there have been studies on myocardial stunning, this head-to-head comparison of TS and STEMI is novel and has not been previously conducted.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * STEMI or TS with planned coronary angiography within 12 hours from the onset of symptoms * Written consent Exclusion Criteria: * Cardiogenic shock, defined as Killip class IV * Expected inability to comply with the protocol
Where this trial is running
Gothenburg
- Department of Cardiology; Sahlgrenska University Hospital — Gothenburg, Sweden (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.